Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE GENETIC DRIFT OF HUMAN PAPILLOMAVIRUS TYPE-16 IS A MEANS OF RECONSTRUCTING PREHISTORIC VIRAL SPREAD AND THE MOVEMENT OF ANCIENT HUMAN-POPULATIONS
Autore:
HO L; CHAN SY; BURK RD; DAS BC; FUJINAGA K; ICENOGLE JP; KAHN T; KIVIAT N; LANCASTER W; MAVROMARANAZOS P; LABROPOULOU V; MITRANIROSENBAUM S; NORRILD B; PILLAI MR; STOERKER J; SYRJAENEN K; SYRJAENEN S; TAY SK; VILLA LL; WHEELER CM; WILLIAMSON AL; BERNARD HU;
Indirizzi:
NATL UNIV SINGAPORE,INST MOLEC & CELL BIOL,PAPILLOMAVIRUS LAB SINGAPORE 0511 SINGAPORE NATL UNIV SINGAPORE,INST MOLEC & CELL BIOL,PAPILLOMAVIRUS LAB SINGAPORE 0511 SINGAPORE UNIV KUOPIO,DEPT PATHOL KUOPIO FINLAND YESHIVA UNIV ALBERT EINSTEIN COLL MED BRONX NY 10461 MAULANA AZAD MED COLL,INST CYTOL & PREVENT ONCOL DELHI 110002 INDIA SAPPORO MED COLL,CANC RES INST,CHUO KU SAPPORO HOKKAIDO 060 JAPAN CTR DIS CONTROL & PREVENT ATLANTA GA 00000 GERMAN CANC RES CTR W-6900 HEIDELBERG 1 GERMANY REG CANC CTR TRIVANDRUM 695011 INDIA UNIV WASHINGTON,HARBORVIEW MED CTR SEATTLE WA 98104 WAYNE STATE UNIV,SCH MED DETROIT MI 48201 CAROLINA MED CTR CHARLOTTE NC 28232 INST PASTEUR HELLEN ATHENS GREECE HADASSAH UNIV HOSP IL-91120 JERUSALEM ISRAEL UNIV COPENHAGEN,PANUM INST DK-2200 COPENHAGEN DENMARK SINGAPORE GEN HOSP SINGAPORE 0316 SINGAPORE LUDWIG INST CANC RES BR-01509 SAO PAULO BRAZIL UNIV NEW MEXICO,CTR CANC,DEPT CELL BIOL ALBUQUERQUE NM 87131 UNIV NEW MEXICO,NEW MEXICO TUMOR REGISTRY ALBUQUERQUE NM 87131 UNIV CAPE TOWN,SCH MED,DEPT MED MICROBIOL CAPE TOWN 7925 SOUTH AFRICA
Titolo Testata:
Journal of virology
fascicolo: 11, volume: 67, anno: 1993,
pagine: 6413 - 6423
SICI:
0022-538X(1993)67:11<6413:TGDOHP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE VARIATION; VARIANTS; COEVOLUTION; EVOLUTION; VIRUS; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Ho et al., "THE GENETIC DRIFT OF HUMAN PAPILLOMAVIRUS TYPE-16 IS A MEANS OF RECONSTRUCTING PREHISTORIC VIRAL SPREAD AND THE MOVEMENT OF ANCIENT HUMAN-POPULATIONS", Journal of virology, 67(11), 1993, pp. 6413-6423

Abstract

We have investigated the diversity of a hypervariable segment of the human papillomavirus type 16 (HPV-16) genome among 301 virus isolates that were collected from 25 different ethnic groups and geographic locations. Altogether, we distinguished 48 different variants that had diversified from one another along five phylogenetic branches. Variants from two of these branches were nearly completely confined to Africa. Variants from a third branch were the only variants identified in Europeans but occurred at lower frequency in all other ethnic groups. A fourth branch was specific for Japanese and Chinese isolates. A small fraction of all isolates from Asia and from indigenous as well as immigrant populations in the Americas formed a fifth branch. Important patterns of HPV-16 phylogeny suggested coevolution of the virus with peopleof the three major human races, namely, Africans, Caucasians, and East Asians. But several minor patterns are indicative of smaller bottlenecks of viral evolution and spread, which may correlate with the migration of ethnic groups in prehistoric times. The colonization of the Americas by Europeans and Africans is reflected in the composition of their HPV-16 variants. We discuss arguments that today's HPV-16 genomes represent a degree of diversity that evolved over a large time span, probably exceeding 200,000 years, from a precursor genome that may haveoriginated in Africa. The identification of molecular variants is a powerful epidemiological and phylogenetic tool for revealing the ancient spread of papillomaviruses, whose trace through the world has not yet been completely lost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:15:53