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Titolo:
RESPIRATORY TRANSFER IMPEDANCE BETWEEN 8 AND 384 HZ IN GUINEA-PIGS BEFORE AND AFTER BRONCHIAL CHALLENGE
Autore:
SOBH JF; LILLY CM; DRAZEN JM; JACKSON AC;
Indirizzi:
CHILDRENS HOSP,DEPT CARDIOL,300 LONGWOOD AVE,FARLEY 2 BOSTON MA 02115 BOSTON UNIV,DEPT BIOMED ENGN,RESP RES LAB BOSTON MA 02215 BRIGHAM & WOMENS HOSP,DEPT MED,COMBINED PROGRAM PULM & CRIT CARE MED BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 82, anno: 1997,
pagine: 172 - 181
SICI:
8750-7587(1997)82:1<172:RTIB8A>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANICAL-PROPERTIES; PULMONARY MECHANICS; FREQUENCY-RESPONSE; INPUT IMPEDANCE; PRESSURE; VOLUME; RATS; DOGS;
Keywords:
NONINVASIVE; FORCED OSCILLATION TECHNIQUE; RESPIRATORY RESISTANCE; RESPIRATORY INERTANCE; RESPIRATORY COMPLIANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Sobh et al., "RESPIRATORY TRANSFER IMPEDANCE BETWEEN 8 AND 384 HZ IN GUINEA-PIGS BEFORE AND AFTER BRONCHIAL CHALLENGE", Journal of applied physiology, 82(1), 1997, pp. 172-181

Abstract

We report a forced oscillatory technique for noninvasively measuring respiratory transfer impedance (Ztr) between 8 and 384 Hz in guinea pigs. This technique uses a device consisting of two chambers: one surrounding the animal's head that is used as a plethysmograph to measured flow through the airway opening and the other that surrounds the animal's body and is used to apply pressure oscillations to the body surface. Ztr was measured in spontaneously breathing awake guinea pigs and while the animals were anesthetized in normal and methacholine-challenged conditions. An eight-element model consisting of an airway compartment separated from a tissue compartment by a shunt gas compression compartment was fit to the data. Anesthesia increased central and peripheral airway resistance and bronchial airway wall compliance by 13, 31, and 44%, respectively, whereas it decreased tissue compliance by 37%. Compared with the unanesthetized condition, the methacholine challenge(20 mu g/mu g) resulted in an increase in central and peripheral airway resistance (69 and 319%, respectively) and a decrease in bronchial airway wall and tissue compliance (37 and 79%, respectively). This technique is capable of measuring Ztr in anesthetized and awake guinea pigs. Analysis of these data with this eight-element model provides reasonable estimates of airway and tissue parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:00:14