Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ATRIAL-NATRIURETIC-PEPTIDE LEVELS AND PLASMA-VOLUME CONTRACTION IN ACUTE ALVEOLAR HYPOXIA
Autore:
ALBERT TSE; TUCKER VL; RENKIN EM;
Indirizzi:
UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL DAVIS CA 95616
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 82, anno: 1997,
pagine: 102 - 110
SICI:
8750-7587(1997)82:1<102:ALAPCI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-HYPERTENSION; ANF RELEASE; RATS; HEMODYNAMICS; ATRIOPEPTIN; MECHANISMS; INCREASES; ALBUMIN; SODIUM; CHEMORECEPTORS;
Keywords:
FLUID BALANCE; CARDIAC OUTPUT; ARTERIAL HYPOXEMIA; BLOOD GASES; PLASMA PROTEIN CONCENTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T.S.E. Albert et al., "ATRIAL-NATRIURETIC-PEPTIDE LEVELS AND PLASMA-VOLUME CONTRACTION IN ACUTE ALVEOLAR HYPOXIA", Journal of applied physiology, 82(1), 1997, pp. 102-110

Abstract

Arterial oxygen tensions (Pa-O2), atrial natriuretic peptide (ANP) concentrations, and circulating plasma volumes (PV) were measured in anesthetized rats ventilated with room air or 15, 10, or 8% O-2 (n = 5-7). After 10 min of ventilation, Pao, values were 80 +/- 3, 46 +/- 1, 32+/- 1, and 35 +/- 1 Torr and plasma immunoreactive ANP (irANP) levelswere 211 +/- 29, 229 +/- 28, 911 +/- 205, and 4,374 +/- 961 pg/ml, respectively. At PaO2 less than or equal to 40 Torr, irANP responses were more closely related to inspired O-2 (P = 0.014) than to Pa-O2 (P = 0.168). PV was 36.3 +/- 0.5 mu l/g in controls but 8.5 and 9.9% lower (P less than or equal to 0.05) for 10 and 8% O-2 respectively. Proportional increases in hematocrit were observed in animals with reduced PV; however, plasma protein concentrations were not different from control. Between 10 and 50 min of hypoxia, small increases (+40%) in irANP occurred in 15% O-2; however, there was no further change in PV, hematocrit, plasma protein, or irANP levels in the lower O-2 groups. Urine output tended to fall during hypoxia but was not significantly different among groups. These findings are compatible with a role for ANP in mediating PV contraction during acute alveolar hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:41:30