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Titolo:
INCREASED CA2-SENSITIVE K+ CHANNELS IN DOG BASILAR ARTERY( INFLUX IN THE RESTING STATE MAINTAINS THE MYOGENIC TONE AND ACTIVATES CHARYBDOTOXIN)
Autore:
ASANO M; MASUZAWAITO K; MATSUDA T; SUZUKI Y; OYAMA H; SHIBUYA M; SUGITA K;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PHARMACOL,MIZUHO KU NAGOYA AICHI 467 JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROSURG NAGOYA AICHI 466 JAPAN
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 6, volume: 13, anno: 1993,
pagine: 969 - 977
SICI:
0271-678X(1993)13:6<969:ICKCID>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; MIDDLE CEREBRAL-ARTERY; SPONTANEOUSLY HYPERTENSIVE RATS; CANINE MESENTERIC-ARTERY; POTASSIUM CHANNELS; FEMORAL ARTERIES; NEUROMUSCULAR-TRANSMISSION; INDUCED CONTRACTIONS; CALCIUM CHANNELS; RB-86 EFFLUX;
Keywords:
BASILAR ARTERY (DOG); VOLTAGE-DEPENDENT CA2+ CHANNELS; TRANSMEMBRANE; CA-45 INFLUX; CA2+-ACTIVATED K+ CHANNELS; CHARYBDOTOXIN-INDUCED CONTRACTION; RB-86 EFFLUX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Asano et al., "INCREASED CA2-SENSITIVE K+ CHANNELS IN DOG BASILAR ARTERY( INFLUX IN THE RESTING STATE MAINTAINS THE MYOGENIC TONE AND ACTIVATES CHARYBDOTOXIN)", Journal of cerebral blood flow and metabolism, 13(6), 1993, pp. 969-977

Abstract

We examined whether Ca2+ channel function in the resting state altersthe resting tone and Ca2+-activated K+ (K(Ca)) channel function in dog basilar artery: data were compared with findings in the mesenteric artery. Isolated dog basilar artery maintained a myogenic tone; that is, the resting tone decreased when either the Krebs solution was replaced with a Ca2+-free solution or nifedipine was added. The basal Ca-45 influx in the resting state of the basilar artery was significantly increased compared with that in the mesenteric artery, and this increasein the basilar artery was reduced by nifedipine. The addition of charybdotoxin (ChTX), a blocker of large-conductance K(Ca) channels, to the resting strips caused a concentration-dependent contraction in the basilar artery but not in the mesenteric artery. The ChTX-induced contraction in the basilar artery was abolished by nifedipine. In resting strips preloaded with Rb-86, the basal Rb-86 efflux rate constant was significantly greater in the basilar artery than in the mesenteric artery. The addition of nifedipine to the resting strips decreased the basal Rb-86 efflux rate constant only in the basilar artery. These results suggest that the transmembrane Ca2+ influx via L-type voltage-dependent Ca2+ channels was significantly increased in the resting state of the basilar artery and that the myogenic tone was therefore maintainedand the ChTX-sensitive K(Ca) channels were highly activated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:37:48