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Titolo:
PRACTICES FOR CYTOMEGALOVIRUS DIAGNOSIS, PROPHYLAXIS AND TREATMENT INALLOGENEIC BONE-MARROW TRANSPLANT RECIPIENTS - A REPORT FROM THE WORKING PARTY FOR INFECTIOUS-DISEASES OF THE EBMT
Autore:
LJUNGMAN P; DEBOCK R; CORDONNIER C; EINSELE H; ENGELHARD D; GRUNDY J; LOCASCIULLI A; REUSSER P; RIBAUD P;
Indirizzi:
HUDDINGE UNIV HOSP,DEPT MED S-14186 HUDDINGE SWEDEN
Titolo Testata:
Bone marrow transplantation
fascicolo: 4, volume: 12, anno: 1993,
pagine: 399 - 403
SICI:
0268-3369(1993)12:4<399:PFCDPA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS IMMUNE GLOBULIN; VIRUS INFECTION; INTERSTITIAL PNEUMONIA; CONTROLLED TRIAL; GANCICLOVIR; PREVENTION; IMMUNOGLOBULIN; COMBINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P. Ljungman et al., "PRACTICES FOR CYTOMEGALOVIRUS DIAGNOSIS, PROPHYLAXIS AND TREATMENT INALLOGENEIC BONE-MARROW TRANSPLANT RECIPIENTS - A REPORT FROM THE WORKING PARTY FOR INFECTIOUS-DISEASES OF THE EBMT", Bone marrow transplantation, 12(4), 1993, pp. 399-403

Abstract

During the past few years major progress has been made in the diagnosis and therapy of CMV infection after allogeneic BMT. The aim of this survey was to investigate the use of diagnostic techniques, use of prophylaxis and the therapeutic strategies among members of the EBMT. Seventy centers from 20 countries responded to the survey. Sixty-seven centers (96%) routinely tried to diagnose CMV from the blood. Fifty-seven centers used standard or rapid isolation techniques. Thirty-seven centers used one of the newly developed techniques, antigenemia detection in leukocytes or PCR together with isolation, while 10 centers used one of these two techniques without standard isolation. Fifty-five centers regularly performed bronchoscopy and bronchoalveolar lavage on the suspicion of CMV pneumonia but only 12 centers required detection ofCMV in specimens from the lavage or lungs as the indication to start therapy, 31 centers started therapy on symptoms of pneumonia combined with CMV detection from any site. Prophylaxis was used in 54 centers (84%). The most commonly used regimen was high-dose acyclovir which wasused by 42 centers, while seven centers used ganciclovir. The strategy of early therapy was used by 53 centers (76%) and was most frequently based on detection of viremia or CMV antigen in the blood. CMV pneumonia was treated by a combination of ganciclovir and iv immunoglobulinby 64 centers, by foscarnet and immunoglobulin in 5 centers and by ganciclovir alone in 5 centers. CMV gastrointestinal disease was treatedby antiviral therapy alone in 18 centers and by a combination of antiviral therapy and iv immunoglobulin in 46 centers. We conclude that the new approaches to CMV diagnosis and therapy are widely used in Europe; major differences exist in the diagnostic criteria for CMV disease and in the criteria for initiating therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:26:33