Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ABILITY OF INTRAUTERINE BACTERIAL LIPOPOLYSACCHARIDE TO CAUSE IN-SITUUTERINE CONTRACTIONS IN PREGNANT RABBITS
Autore:
KATSUKI Y; KAGA N; KAKINUMA C; TAKAGAKI K; KAJIKAWA S; SHIBUTANI Y;
Indirizzi:
MOCHIDA PHARMACEUT CO LTD,TOXICOL LAB,342 GENSUKE FUJIEDA SHIZUOKA 426 JAPAN
Titolo Testata:
Acta obstetricia et gynecologica Scandinavica
fascicolo: 1, volume: 76, anno: 1997,
pagine: 26 - 32
SICI:
0001-6349(1997)76:1<26:AOIBLT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRETERM LABOR; INFECTION; MODEL;
Keywords:
LIPOPOLYSACCHARIDE; PROSTAGLANDIN PRODUCTION; RABBITS; URINARY TRYPSIN INHIBITOR; UTERINE CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
Y. Katsuki et al., "ABILITY OF INTRAUTERINE BACTERIAL LIPOPOLYSACCHARIDE TO CAUSE IN-SITUUTERINE CONTRACTIONS IN PREGNANT RABBITS", Acta obstetricia et gynecologica Scandinavica, 76(1), 1997, pp. 26-32

Abstract

Background. To investigate the ability of bacterial lipopolysaccharide delivered by the intrauterine route to cause uterine contractions inrabbits, and to assess the suppressive effect of urinary trypsin inhibitor on them. Methods. Both pregnant and non-pregnant rabbits were chronically implanted with a force-transducer to make it possible to record isometric uterine contractions under unanesthetized and unrestrained conditions. Lipopolysaccharide (10 mu g/animal) was administered via a catheter to their uteri; and then, after confirmation of lipopolysaccharide-induced uterine contractions, urinary trypsin inhibitor (3,000 or 10,000 units/animal/time) or saline solution was injected through the catheter, 5 times for pregnant animals or 3 times for non-pregnant animals at 1-hour intervals in both cases. Their uterine contractions were continuously recorded for 3 to 5 hours. Effects of lipopolysaccharide (10 mu g/ml) and urinary trypsin inhibitor (100 and 1,000 units/ml) on the contraction of isolated uteri from pregnant mice were also measured, as was their production of prostaglandin E2 and prostaglandin F2 alpha by an enzyme immunoassay method. Results. Lipopolysaccharide augmented the in situ uterine contractions in both pregnant and non-pregnant rabbits, as well as the in vitro contractions of isolated uteri from pregnant mice. Lipopolysaccharide also increased the uterineprostaglandin production. Urinary trypsin inhibitor inhibited significantly the lipopolysaccharide-induced uterine contractions and the prostaglandin production. Conclusions. Lipopolysaccharide enhanced uterine contractions through, at least partly, a direct mechanism via uterine prostaglandin production, which action could explain the onset of preterm delivery due to intrauterine bacterial infection. As urinary trypsin inhibitor suppressed the lipopolysaccharide-induced uterine contractions, this inhibitor may be a hopeful candidate of a drug for prevention of preterm delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:53:26