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Titolo:
SEXUALLY AROUSING EVENTS AND RELAPSE TO HEROIN-SEEKING IN SEXUALLY EXPERIENCED MALE-RATS
Autore:
SHAHAM Y; PUDDICOMBE J; STEWART J;
Indirizzi:
CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL,1455 MAISONNEUVE BLVD MONTREAL PQ H3G 1M8 CANADA CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL MONTREAL PQ H3G 1M8 CANADA
Titolo Testata:
Physiology & behavior
fascicolo: 2, volume: 61, anno: 1997,
pagine: 337 - 341
SICI:
0031-9384(1997)61:2<337:SAEART>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ADMINISTRATION BEHAVIOR; DRUG-REINFORCED BEHAVIOR; FOOD-DEPRIVATION; REINSTATEMENT; DOPAMINE; EXTINCTION; MORPHINE; WITHDRAWAL; DEPENDENCE; OPIOIDS;
Keywords:
HEROIN; INTRAVENOUS DRUG SELF-ADMINISTRATION; MALE RATS; SEXUALLY ACTIVE FEMALE RATS; RELAPSE; REINSTATEMENT; SEXUAL AROUSAL; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Y. Shaham et al., "SEXUALLY AROUSING EVENTS AND RELAPSE TO HEROIN-SEEKING IN SEXUALLY EXPERIENCED MALE-RATS", Physiology & behavior, 61(2), 1997, pp. 337-341

Abstract

We have shown previously, using a reinstatement procedure, that both priming injections of heroin and exposure to footshock stress reinstate heroin-taking behavior following prolonged drug-free periods. In thepresent study, we examined the effects of another highly arousing event, exposure to a sexually active female, on reinstatement of heroin-seeking. Male rats were first given sexual experience, being allowed tocopulate on 4 occasions with sexually active females and were then trained to self-administer heroin (100 mu g/kg per infusion, IV) for 4 3-h sessions/day for 5-6 days and 1 6-h session/day for an additional 6days. Extinction sessions were then given for 4 days, 6-h/day, duringwhich saline was substituted for heroin. On tests for reinstatement, males were presented with: 1. The wire-mesh side of an empty cage (baseline condition), 2. the sight, odor, and smell of a sexually inactivefemale, 3. the sight, odor, and smell of a female in heat, 4, a female in heat, and allowed to copulate, 5. intermittent footshock (15 min,0.5 mA, 0.5 s on, mean off period of 40 s), or 6. a priming injectionof heroin (0.25 mg/kg, SC). Reinstatement of heroin-taking behavior was observed after exposure to the priming injection of heroin and to footshock stress. Reinstatement of heroin-taking behavior was not induced by exposure to the females in any of the conditions. Thus, motivational arousal, as such, does not appear to be a sufficient stimulus forrelapse to heroin-taking. Copyright (C) 1997 Elsevier Science Inc.

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Documento generato il 11/07/20 alle ore 17:45:58