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Titolo:
THE DIAGNOSTIC USE OF LOW-MOLECULAR-WEIGHT KERATIN EXPRESSION IN SEBACEOUS CARCINOMA
Autore:
MURATA T; NAKASHIMA Y; TAKEUCHI M; SUEISHI K; INOMATA H;
Indirizzi:
KYUSHU UNIV 60,FAC MED,DEPT PATHOL,3-1-1 MAIDASHI,HIGASHI KU FUKUOKA 812 JAPAN KYUSHU UNIV,FAC MED,DEPT OPHTHALMOL FUKUOKA 812 JAPAN
Titolo Testata:
Pathology research and practice
fascicolo: 8, volume: 189, anno: 1993,
pagine: 888 - 893
SICI:
0344-0338(1993)189:8<888:TDUOLK>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEINS; MONOCLONAL-ANTIBODIES; OCULAR ADNEXA; TUMORS; CELLS;
Keywords:
SEBACEOUS CARCINOMA; SQUAMOUS CELL CARCINOMA; BASAL CELL EPITHELIOMA; KERATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Murata et al., "THE DIAGNOSTIC USE OF LOW-MOLECULAR-WEIGHT KERATIN EXPRESSION IN SEBACEOUS CARCINOMA", Pathology research and practice, 189(8), 1993, pp. 888-893

Abstract

Sebaceous carcinoma is an infrequent skin tumor and its histological features sometimes closely resemble those of squamous cell carcinoma (SCC) and basal cell epithelioma (BCE), which often leads to a misdiagnosis. In the present immunohistochemical study, however, sebaceous carcinoma exhibited quite a different expression of keratins from SCC andBCE. We immunohistochemically examined 2 6 excised specimens of sebaceous carcinoma, 10 of SCC and 12 of BCE of the eyelids, using two monoclonal antibodies against high molecular weight keratins, 34betaB4 (68kd) and 34betaE12 (56kd, 56.5kd, 58kd), and two monoclonal antibodies against low molecular weight keratins, 35betaH11 (54kd) and CAM5.2 (39kd, 43kd, 50kd). The cases of sebaceous carcinoma were positive with 34betaB4 (23%), 34betaE12 (54%), 35betaH11 (81%) and CAMS.2 (73%). Of the four anti-keratin antibodies used in this study, 35betaH11 was negative in all cases of SCC or BCE. These findings indicate that when sebaceous carcinoma is suspected, but no fat staining appropriate materials are available, a monoclonal antibody against low molecular weight keratin, 35betaH11 (54kd), can be a useful tool to immunohistochemically rule out both SCC and BCE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:10:15