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Titolo:
IDENTIFICATION AND CHARACTERIZATION OF PENTON BASE AND PVIII PROTEIN OF EGG DROP SYNDROME VIRUS
Autore:
ROHN K; PRUSAS C; MONREAL G; HESS M;
Indirizzi:
FREE UNIV BERLIN,INST GEFLUGELKRANKHEITEN,KOSERSTR 21 D-14195 BERLIN GERMANY FREE UNIV BERLIN,INST GEFLUGELKRANKHEITEN D-14195 BERLIN GERMANY
Titolo Testata:
Virus research
fascicolo: 1, volume: 47, anno: 1997,
pagine: 59 - 65
SICI:
0168-1702(1997)47:1<59:IACOPB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
AVIAN ADENOVIRUS PENTON; DNA; SEQUENCE; ADHESION;
Keywords:
AVIAN ADENOVIRUS; EGG DROP SYNDROME VIRUS; PENTON BASE PROTEIN; PVIII PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Rohn et al., "IDENTIFICATION AND CHARACTERIZATION OF PENTON BASE AND PVIII PROTEIN OF EGG DROP SYNDROME VIRUS", Virus research, 47(1), 1997, pp. 59-65

Abstract

The nucleotide sequence and location of the penton base and pVIII genes of the egg drop syndrome (EDS) virus, an avian adenovirus, were determined. The penton base gene is located at 34.8-38.8 map units. The coding sequence has a length of 1359 nt and encodes a polypeptide of 452 amino acids (aa) with a molecular weight of 51 105 Da. The amino acid sequence shows a homology of 57.3 and 55.3% to the structural protein III of human adenovirus serotype 2 (HAd2) and fowl adenovirus serotype 1 (FAV1). The penton base protein lacks the integrin binding motifsRGD (Arg-Gly-Asp) and LDV (Leu-Asp-Val). At 65.1-67.3 map units an open reading frame of 753 nucleotides was identified which encodes the structural protein pVIII. It forms a protein of 250 aa with an expectedmolecular weigth of 28 501 Da. Possible protease cleavage sites were identified. Amino acid homologies of 30.8 and 27.7% were found to the HAd2 and FAV1 pVIII genes. Remarkably, the overall amino acid identitywith ovine adenovirus pVIII is 52%. The start codons of both genes are shifted leftwards compared with the respective structural elements on the HAd2 or FAV1 genomes which indicates a different genomic organization of the EDS virus. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:09:35