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Titolo:
MICROORGANISMS IN THE GASTROINTESTINAL-TRACT OF THE RAT PREVENT ABSORPTION OF THE MUTAGEN CARCINOGEN 3-AMINO-1,4-DIMETHYL-5H-PYRIDO(4,3-B)INDOLE
Autore:
ZHANG XB; OHTA Y;
Indirizzi:
YORK UNIV,DEPT BIOL N YORK M3J 1P3 ONTARIO CANADA HIROSHIMA UNIV,FAC APPL BIOL SCI,MICROBIAL BIOCHEM LAB HIGASHIHIROSHIMA 724 JAPAN
Titolo Testata:
Canadian journal of microbiology
fascicolo: 9, volume: 39, anno: 1993,
pagine: 841 - 845
SICI:
0008-4166(1993)39:9<841:MITGOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROCYCLIC AMINES; INVITRO BINDING; BACTERIAL-CELLS; ANTIMUTAGENICITY; PYROLYSATE; FRACTIONS; FIBER; MICE; MEIQ; FOOD;
Keywords:
TRP-P-1; GASTROINTESTINAL ABSORPTION; BINDING; INTESTINAL BACTERIA; MUTAGEN-CARCINOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
X.B. Zhang e Y. Ohta, "MICROORGANISMS IN THE GASTROINTESTINAL-TRACT OF THE RAT PREVENT ABSORPTION OF THE MUTAGEN CARCINOGEN 3-AMINO-1,4-DIMETHYL-5H-PYRIDO(4,3-B)INDOLE", Canadian journal of microbiology, 39(9), 1993, pp. 841-845

Abstract

The extent to which lactic acid bacteria, intestinal bacteria, and yeast from the gastrointestinal tract of rats suppress the absorption of3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1) was investigated. Trp-P-1 was absorbed from the small intestine very rapidly, but in the stomach it was slowly absorbed, requiring 1 or 2 h after administration. When mixtures of Trp-P-1 and freeze-dried microorganisms were administered to rats for 1 h, the amounts of Trp-P-1 absorbed from the small intestine were significantly reduced, and the levels of Trp-P-1 in blood decreased by 40.4-64.7% compared with a control in which onlyTrp-P-1 was administered. There were no significant differences between the organisms used. In vitro, freeze-dried cells of the strains tested bound 51-97% of Trp-P-1. The Trp-P-1 bound to cells was effectively extracted by aqueous methanol, ethanol, ammonia (50 g/L), and solutions Of MgCl2 and CaCl2 (100 mM/mL), but little was extracted b water and solutions of KCl, NaCl, and buffers at various pH values.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:50:04