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Titolo:
ORGANIZATION AND EVOLUTION OF AN ALPHA-SATELLITE DNA SUBSET SHARED BYHUMAN CHROMOSOME-13 AND CHROMOSOME-21
Autore:
GREIG GM; WARBURTON PE; WILLARD HF;
Indirizzi:
STANFORD UNIV,DEPT GENET STANFORD CA 94305 STANFORD UNIV,DEPT GENET STANFORD CA 94305 CASE WESTERN RESERVE UNIV,SCH MED,CTR HUMAN GENET,DEPT GENET CLEVELAND OH 44106
Titolo Testata:
Journal of molecular evolution
fascicolo: 5, volume: 37, anno: 1993,
pagine: 464 - 475
SICI:
0022-2844(1993)37:5<464:OAEOAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ACROCENTRIC CHROMOSOMES; LONG-RANGE ORGANIZATION; UNEQUAL CROSSING-OVER; TANDEMLY REPEATED DNA; HUMAN X-CHROMOSOME; ROBERTSONIAN TRANSLOCATIONS; GENOMIC DISTRIBUTION; SEQUENCE VARIATION; PCR AMPLIFICATION; MOLECULAR DRIVE;
Keywords:
HUMAN CHROMOSOME-13 AND CHROMOSOME-21; TANDEMLY REPEATED DNA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; INTERCHROMOSOMAL AND INTRACHROMOSOMAL HOMOGENIZATION; EVOLUTION OF SATELLITE DNA; ANCESTRAL REPEAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Greig et al., "ORGANIZATION AND EVOLUTION OF AN ALPHA-SATELLITE DNA SUBSET SHARED BYHUMAN CHROMOSOME-13 AND CHROMOSOME-21", Journal of molecular evolution, 37(5), 1993, pp. 464-475

Abstract

The structure of the alpha satellite DNA higher-order repeat (HOR) unit from a subset shared by human chromosomes 13 and 21 (D13Z1 and D21Z1) has been examined in detail. By using a panel of hybrids possessingeither a chromosome 13 or a chromosome 21, different HOR unit genotypes on chromosomes 13 and 21 have been distinguished. We have also determined the basis for a variant HOR unit structure found on approximately 8% of chromosomes 13 but not at all on chromosomes 21. Genomic restriction maps of the HOR units found on the two chromosome 13 genotypesand on the chromosome 21 genotype are constructed and compared. The nucleotide sequence of a predominant 1.9-kilobasepair HOR unit from theD13Z1/D21Z1 subset has been determined. The DNA sequences of different alpha satellite monomers comprising the HOR are compared, and the data are used to develop a model, based on unequal crossing-over, for the evolution of the current HOR unit found at the centromeres of both these chromosomes.

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Documento generato il 18/09/20 alle ore 17:01:28