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Titolo:
TITIN ANTIBODIES IN MYASTHENIA-GRAVIS - IDENTIFICATION OF A MAJOR IMMUNOGENIC REGION OF TITIN
Autore:
GAUTEL M; LAKEY A; BARLOW DP; HOLMES Z; SCALES S; LEONARD K; LABEIT S; MYGLAND A; GILHUS NE; AARLI JA;
Indirizzi:
UNIV BERGEN,HAUKELAND HOSP,DEPT NEUROL N-5021 BERGEN NORWAY UNIV BERGEN,HAUKELAND HOSP,DEPT NEUROL N-5021 BERGEN NORWAY EUROPEAN MOLEC BIOL LAB W-6900 HEIDELBERG GERMANY INST MOLEC PATHOL VIENNA AUSTRIA
Titolo Testata:
Neurology
fascicolo: 8, volume: 43, anno: 1993,
pagine: 1581 - 1585
SICI:
0028-3878(1993)43:8<1581:TAIM-I>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOMA; AUTOANTIBODIES; SEQUENCES; DIAGNOSIS; ANTIGEN; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Gautel et al., "TITIN ANTIBODIES IN MYASTHENIA-GRAVIS - IDENTIFICATION OF A MAJOR IMMUNOGENIC REGION OF TITIN", Neurology, 43(8), 1993, pp. 1581-1585

Abstract

Approximately 15% of patients with myasthenia gravis (MG) have thymusneoplasia. These MG with thymoma (MGT) patients show autoantibodies to striated muscle as well as autoantibodies to acetylcholine receptor. To characterize these thymoma-associated muscle antigens, we cloned anumber of immunopositive cDNAs by immunoscreening muscle cDNA libraries with sera from MGT patients. Analysis of the isolated cDNAs show that all share a common sequence encoding a distinct region of the titingene. We expressed this main immunogenic region (MIR) of titin in Escherichia coli, and determined autoantibody serum titers directed against the obtained recombinant antigen in a variety of patients. We coulddetect titin MIR autoantibodies in 97% of sera from MGT patients but not in control sera from healthy blood donors. Therefore, expressed titin from the MIR of the molecule is a sensitive marker antigen for evaluating the presence of thymoma in MG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:20:27