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Titolo:
LDL SUBCLASS PHENOTYPES AND THE INSULIN-RESISTANCE SYNDROME IN WOMEN
Autore:
SELBY JV; AUSTIN MA; NEWMAN B; ZHANG D; QUESENBERRY CP; MAYER EJ; KRAUSS RM;
Indirizzi:
KAISER PERMANENTE MED CARE PROGRAM,DIV RES,3451 PIEDMONT AVE OAKLAND CA 94611 UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL CHAPEL HILL NC 27514 LAWRENCE BERKELEY LAB,DONNER LAB BERKELEY CA 94720 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL SEATTLE WA 98195
Titolo Testata:
Circulation
fascicolo: 2, volume: 88, anno: 1993,
pagine: 381 - 387
SICI:
0009-7322(1993)88:2<381:LSPATI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; CORONARY-ARTERY DISEASE; DYSLIPIDEMIC HYPERTENSION; GLUCOSE-TOLERANCE; PARTICLE-SIZE; HEART-DISEASE; NHLBI TWIN; PATTERNS; RISK; HETEROGENEITY;
Keywords:
INSULIN RESISTANCE; HYPERTENSION; HUMAN GENETICS; TWIN; LOW-DENSITY LIPOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Selby et al., "LDL SUBCLASS PHENOTYPES AND THE INSULIN-RESISTANCE SYNDROME IN WOMEN", Circulation, 88(2), 1993, pp. 381-387

Abstract

Background. Low-density lipoprotein (LDL) subclass phenotype B, characterized by predominance of small, dense LDL particles, is associated with elevated plasma triglycerides and apolipoprotein B and with lowerhigh-density lipoprotein (HDL) cholesterol and apolipoprotein A-I. Because these abnormalities resemble the dyslipidemia of insulin resistance, we examined associations of LDL subclass phenotype with plasma insulin levels and with other aspects of the insulin resistance syndrome. Methods and Results. LDL subclass phenotypes were determined by gradient gel electrophoresis in 682 female twins aged 30 to 91 years who participated in the second examination of the Kaiser Permanente Women Twins Study. Prevalence of phenotype B and the intermediate phenotype (I) increased strongly with age, obesity, and non-insulin-dependent diabetes. In multivariate analysis of nondiabetic women, phenotype B or Iwas independently associated with each aspect of the insulin resistance syndrome, including higher plasma triglycerides, waist-hip ratio, fasting and postload insulin levels, and systolic blood pressure and lower HDL cholesterol levels after adjustment for age and body mass index. The prevalence of phenotype B or I rose progressively from 5.6% in women with no manifestations of the insulin resistance syndrome to 100% in women with four syndrome components. In 25 nondiabetic, monozygotic twin pairs discordant for subclass phenotype, the twins with phenotype B (or I) had significantly higher levels of body mass index, waist-hip ratio, and systolic blood pressure than their twins with phenotype A. Thus, nongenetic variation in these risk factors is important in explaining their associations with LDL subclass phenotype. Conclusions. Small, dense LDL is an integral feature of the insulin resistance syndrome. Nongenetic (ie, behavioral or environmental) factors are important for the expression of the phenotype and for its association with other heart disease risk factors.

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Documento generato il 28/11/20 alle ore 09:59:04