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Titolo:
RESPONSE OF NEURONS IN THE LATERAL SUPERIOR OLIVE AND MEDIAL NUCLEUS OF THE TRAPEZOID BODY TO REPETITIVE STIMULATION - INTRACELLULAR AND EXTRACELLULAR RECORDINGS FROM MOUSE-BRAIN SLICE
Autore:
WU SH; KELLY JB;
Indirizzi:
CARLETON UNIV,DEPT PSYCHOL,SENSORY NEUROSCI LAB,329 LIFE SCI BLDG OTTAWA K1S 5B6 ONTARIO CANADA CARLETON UNIV,DEPT PSYCHOL,SENSORY NEUROSCI LAB,329 LIFE SCI BLDG OTTAWA K1S 5B6 ONTARIO CANADA
Titolo Testata:
Hearing research
fascicolo: 2, volume: 68, anno: 1993,
pagine: 189 - 201
SICI:
0378-5955(1993)68:2<189:RONITL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTEROVENTRAL COCHLEAR NUCLEUS; UNIT EXCITATORY RESPONSES; SINGLE AUDITORY UNITS; BINAURAL TONE BURSTS; BUSHY CELL AXONS; SOUND LOCALIZATION; PHYSIOLOGICAL-PROPERTIES; HORSERADISH-PEROXIDASE; DISCHARGE PATTERNS; EPTESICUS-FUSCUS;
Keywords:
SUPERIOR OLIVARY COMPLEX; TRAPEZOID BODY; SOUND LOCALIZATION; BINAURAL INTEGRATION; ACOUSTIC CHIASM; TEMPORAL RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Wu e J.B. Kelly, "RESPONSE OF NEURONS IN THE LATERAL SUPERIOR OLIVE AND MEDIAL NUCLEUS OF THE TRAPEZOID BODY TO REPETITIVE STIMULATION - INTRACELLULAR AND EXTRACELLULAR RECORDINGS FROM MOUSE-BRAIN SLICE", Hearing research, 68(2), 1993, pp. 189-201

Abstract

The responses of neurons in the lateral superior olive (LSO) and medial nucleus of the trapezoid body (MNTB) to repeated electrical stimulation of the trapezoid body were investigated in a brain slice preparation of the mouse superior olivary complex. Brain slices, 400-500 mum thick, were cut in the frontal plane and were maintained for physiological recording in a bath of warm, oxygenated saline. Both intracellularand extracellular recordings were made with glass micropipettes filled with 4 M potassium acetate. Bipolar stimulating electrodes were placed on the trapezoid body ipsilateral and contralateral to the superiorolive. Current levels were set so that an ipsilateral pulse elicited a single action potential in LSO and a contralateral pulse elicited a single action potential in MNTB. Trapezoid body fibers were then stimulated with trains consisting of 10 current pulses. Repeated stimulation at low rates resulted in a number of spikes equal to the number of current pulses. Pulse rate was then increased to determine the limits of response to repeated stimulation. In the MNTB, neurons were capable of following very high rates of stimulation without reduction in response probability. On the average, MNTB neurons responded with a probability of 0.9 at 667 Hz. In contrast, most LSO neurons were incapable offollowing high rates of stimulation. LSO neurons responded with a probability of 0.9 at 125 Hz. For some LSO neurons, application of strychnine (0.5 muM) to the bath increased the probability of firing at highrates. MNTB neurons were unaffected by strychnine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:13:14