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Titolo:
SOMATOSTATIN RECEPTOR SCINTIGRAPHY WITH [IN-111-DTPA-D-PHE(1)]- AND [I-123-TYR(3)]-OCTREOTIDE - THE ROTTERDAM EXPERIENCE WITH MORE THAN 1000 PATIENTS
Autore:
KRENNING EP; KWEKKEBOOM DJ; BAKKER WH; BREEMAN WAP; KOOIJ PPM; OEI HY; VANHAGEN M; POSTEMA PTE; DEJONG M; REUBI JC; VISSER TJ; REIJS AEM; HOFLAND LJ; KOPER JW; LAMBERTS SWJ;
Indirizzi:
ERASMUS UNIV ROTTERDAM,HOSP DIJKZIGT,DEPT NUCL MED,DR MOLEWATERPLEIN 40 ROTTERDAM NETHERLANDS UNIV BERN,INST PATHOL CH-3000 BERN SWITZERLAND ERASMUS UNIV ROTTERDAM,HOSP DIJKZIGT,DEPT INTERNAL MED 3 ROTTERDAM NETHERLANDS
Titolo Testata:
European journal of nuclear medicine
fascicolo: 8, volume: 20, anno: 1993,
pagine: 716 - 731
SICI:
0340-6997(1993)20:8<716:SRSW[A>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; ENDOCRINE TUMORS; POSITIVE TUMORS; EGF-RECEPTORS; BIOCHEMICAL-CHARACTERIZATION; RADIOIODINATED ANALOG; IN-111 PENTATREOTIDE; INVIVO APPLICATION; PANCREATIC TUMORS; INVITRO DETECTION;
Keywords:
SOMATOSTATIN; OCTREOTIDE; TUMOR TARGETING; RECEPTOR IMAGING; APUDOMA; LYMPHOMA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Krenning et al., "SOMATOSTATIN RECEPTOR SCINTIGRAPHY WITH [IN-111-DTPA-D-PHE(1)]- AND [I-123-TYR(3)]-OCTREOTIDE - THE ROTTERDAM EXPERIENCE WITH MORE THAN 1000 PATIENTS", European journal of nuclear medicine, 20(8), 1993, pp. 716-731

Abstract

Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastasesby scintigraphy with the radiolabelled somatostatin analogue octreotide. In addition granulomas and autoimmune processes can be visualized because of local accumulation of somatostatin receptor-positive activated mononuclear leucocytes. In many instances a positive scintigram predicts a favourable response to treatment with octreotide. It is tempting to speculate that octreotide labelled with an appropriate radionuclide might be used in cancer therapy. The successful application of radiolabelled octreotide in scintigraphy indicates the possible usefulness of other radiolabelled peptides, either native peptides or derivatives of these, in, for example, nuclear oncology. The small size of these peptides, e. g. bombesin and substance P, is of the utmost importance for a relatively fast blood clearance, thus leading to low background radioactivity. In this way peptides are powerful alternatives to (fragments of) monoclonal antibodies, the application of which to scintigraphic localization of specific cell surface antigen-bearing tumours is plagued by slow blood clearance and, hence, high background levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:17:31