Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHRONIC REGULATION OF THE NA H ANTIPORTER
Autore:
ALPERN RJ; YAMAJI Y; CANO A; HORIE S; MILLER RT; MOE OW; PREISIG PA;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DIV NEPHROL,5323 HARRY HINES BLVD DALLAS TX 75235
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 2, volume: 122, anno: 1993,
pagine: 137 - 140
SICI:
0022-2143(1993)122:2<137:CROTNH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL TUBULE CELLS; PROTEIN-KINASE-C; METABOLIC-ACIDOSIS; MOLECULAR-CLONING; EXPRESSION; ADAPTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Alpern et al., "CHRONIC REGULATION OF THE NA H ANTIPORTER", The Journal of laboratory and clinical medicine, 122(2), 1993, pp. 137-140

Abstract

This review focuses on studies from our laboratory investigating the mechanisms of chronic regulation of the Na/H antiporter in renal and nonrenal cells. Tissue culture provides an ideal tool for investigatingthis problem because it avoids many complicating effects that would occur in an intact animal during a chronic study. Chronic decreases in extracellular fluid pH cause an increase in Na/H antiporter activity that is dependent on protein synthesis and associated with an increase in NHE-1 (isoform of the sodium-hydrogen antiporter) mRNA abundance. This effect is associated with acid-induced increases in a number of immediate early genes, including c-fos, c-jun, junB, and egr-1. In primary cultures of rabbit proximal tubule cells, activation of protein kinase C for 2 hours causes an increase in Na/H antiporter activity that persists 24 hours later, is dependent on transcription and translation, and is associated with an increase in NHE-1 mRNA abundance. Chronic activation of protein kinase A in opossum kidney (OKP) cells causes anincrease in Na/H antiporter activity that persists 16 to 20 hours later and is dependent on protein synthesis. This latter effect is of particular interest because it is opposite in direction to the acute inhibitory effect of protein kinase A on the Na/H antiporter in these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:58:15