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Titolo:
THE SUSCEPTIBILITY OF THE MALARIAL PARASITE PLASMODIUM-FALCIPARUM TO QUINOLINE-CONTAINING DRUGS IS CORRELATED TO THE LIPID-COMPOSITION OF THE INFECTED ERYTHROCYTE-MEMBRANES
Autore:
SHALMIEV G; GINSBURG H;
Indirizzi:
HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL
Titolo Testata:
Biochemical pharmacology
fascicolo: 3, volume: 46, anno: 1993,
pagine: 365 - 374
SICI:
0006-2952(1993)46:3<365:TSOTMP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATIONIC AMPHIPHILIC DRUGS; LYSOSOMAL PHOSPHOLIPASE-A; CONTAINING ANTIMALARIALS; FERRIPROTOPORPHYRIN-IX; HEMOGLOBIN DEGRADATION; CELL-MEMBRANE; CHLOROQUINE; RESISTANCE; INVITRO; MONOLAYERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
G. Shalmiev e H. Ginsburg, "THE SUSCEPTIBILITY OF THE MALARIAL PARASITE PLASMODIUM-FALCIPARUM TO QUINOLINE-CONTAINING DRUGS IS CORRELATED TO THE LIPID-COMPOSITION OF THE INFECTED ERYTHROCYTE-MEMBRANES", Biochemical pharmacology, 46(3), 1993, pp. 365-374

Abstract

The anti-malarial action of quinoline-containing compounds depends onvarious membrane-related processes, and drug resistance could depend,among other factors, on the membrane lipid composition. To verify this hypothesis, the constitution of phospholipid classes and the contentof cholesterol of various strains of Plasmodium falciparum-infected human erythrocytes grown in in vitro cultures have been assessed in conjunction with drug susceptibility. It was found that uninfected erythrocytes in the culture serve as a major source for the increased lipid content of malaria-infected cells. Alterations of the phospholipid composition of infected cells that result from parasite lipid metabolism are also reflected in the constitution of uninfected red cells, implying lipid exchange between infected and uninfected cells. An inverse relationship between the content of acidic phospholipids and cholesterolhas been observed. Some strains resistant to chloroquine and quinine were sensitive to mefloquine, and vice versa. Resistance to chloroquine or quinine was found to be directly related to the content of acidicphospholipids, while that of mafloquine displayed an inverse correlation. Concomitantly, the resistance to chloroquine was inversely related to the content of cholesterol, while the sensitivity to mefloquine decreased with cholesterol concentration. The possible mechanisms that could account for these observations are briefly discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:38:44