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Titolo:
FUNCTIONAL IMAGING, THE FRONTAL LOBES, AND DEMENTIA
Autore:
FRIEDLAND RP; KOSS E; LERNER A; HEDERA P; ELLIS W; DRONKERS N; OBER BA; JAGUST WJ;
Indirizzi:
UNIV HOSP CLEVELAND,CTR ALZHEIMER,2074 ABINGTON RD CLEVELAND OH 44106 UNIV CALIF DAVIS,DEPT NEUROL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT PATHOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT APPL BEHAV SCI DAVIS CA 95616
Titolo Testata:
Dementia
fascicolo: 3-4, volume: 4, anno: 1993,
pagine: 192 - 203
SICI:
1013-7424(1993)4:3-4<192:FITFLA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; NON-ALZHEIMER TYPE; CORTICAL GLUCOSE-UTILIZATION; PICKS DISEASE; COMPUTED-TOMOGRAPHY; PRESENILE-DEMENTIA; DIFFERENTIAL-DIAGNOSIS; METABOLIC ASYMMETRIES; ANTERIOR-POSTERIOR;
Keywords:
DEMENTIA; FRONTAL LOBE DEMENTIA; PICKS DISEASE; POSITRON EMISSION TOMOGRAPHY; SCOPOLAMINE; ECHOLALIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Friedland et al., "FUNCTIONAL IMAGING, THE FRONTAL LOBES, AND DEMENTIA", Dementia, 4(3-4), 1993, pp. 192-203

Abstract

A 58-year-old man developed progressive difficulty with comprehensionand verbal output with dementia. Positron emission tomography with F-18 2-fluoro-2-deoxy-D-glucose demonstrated asymmetrical frontal and anterior temporal lobe loss of glucose use. Scopolamine infusion (0.3 mg) did not influence memory. Postmortem studies revealed evidence of Pick's disease, with Pick bodies, loss of somatostatin, preservation of choline acetyltransferase and immunostaining with neurofilament antibodies. Pharmacological challenge and positron imaging offer valuable means for the noninvasive assessment of dementing illness. The contributions of functional imaging to our knowledge of frontal involvement in dementing illness are reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:51:40