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Titolo:
EFFECTS OF LATE REPERFUSION ON INFARCT EXPANSION AND INFARCT HEALING IN CONSCIOUS RATS
Autore:
MORITA M; KAWASHIMA S; UENO M; KUBOTA A; IWASAKI T;
Indirizzi:
HYOGO MED UNIV,DEPT MED 1,1-1 MUKOGAWA CHO NISHINOMIYA HYOGO 663 JAPAN HYOGO MED UNIV,DEPT MED 1,1-1 MUKOGAWA CHO NISHINOMIYA HYOGO 663 JAPAN HYOGO MED UNIV,DEPT PATHOL 1 NISHINOMIYA HYOGO 663 JAPAN
Titolo Testata:
The American journal of pathology
fascicolo: 2, volume: 143, anno: 1993,
pagine: 419 - 430
SICI:
0002-9440(1993)143:2<419:EOLROI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY REPERFUSION; IMPROVED SURVIVAL; ANESTHETIZED DOG; TIME COURSE; OCCLUSION; SIZE; HEMORRHAGE; LIMITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Morita et al., "EFFECTS OF LATE REPERFUSION ON INFARCT EXPANSION AND INFARCT HEALING IN CONSCIOUS RATS", The American journal of pathology, 143(2), 1993, pp. 419-430

Abstract

We examined the effects of late reperfusion on infarct expansion and infarct healing process in conscious rats. Coronary occlusion and reperfusion were carried out in conscious rats 1 week after appropriate surgical preparations. The rats were randomized into the following four groups: sham operated, permanent occlusion. early reperfusion (i.e., reperfusion performed 1 hour after occlusion), and late reperfusion (i.e., reperfusion performed 6 hours after occlusion). Histological examination was performed 7 days after coronary occlusion. In the early reperfusion group, infarct size and expansion were reduced when compared to the permanent occlusion group. In rats subjected to late reperfusion, infarct size and expansion were not different from those in the permanent occlusion group. The extent of unresorbed necrotic myocardium in areas of infarcted scar was reduced in both early and late reperfusion groups. Infiltration by neutrophilic cells into areas of necrotic myocardium 16 hours after myocardial infarction was increased in both reperfusion groups. Infiltration by macrophages 3 days after infarctionwas also increased in both reperfusion groups. Late reperfusion, therefore, does not effect infarct expansion, but does contribute to the acceleration of the infarct healing process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:31:56