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Titolo:
THE EFFECT OF INTRATHECAL ADMINISTRATION OF RP67580, A POTENT NEUROKININ-1 ANTAGONIST ON NOCICEPTIVE TRANSMISSION IN THE RAT SPINAL-CORD
Autore:
CHAPMAN V; DICKENSON AH;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT PHARMACOL,GOWER ST LONDON WC1E 6BT ENGLAND
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 157, anno: 1993,
pagine: 149 - 152
SICI:
0304-3940(1993)157:2<149:TEOIAO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; IMMUNOREACTIVE SUBSTANCE-P; RECEPTOR ANTAGONIST; FORMALIN TEST; CAT; STIMULATION; PAIN; CP-96,345; RELEASE; (+/-)-CP-96,345;
Keywords:
RAT; SPINAL CORD; NOCICEPTION; NK1 RECEPTOR; RP67580; FORMALIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
V. Chapman e A.H. Dickenson, "THE EFFECT OF INTRATHECAL ADMINISTRATION OF RP67580, A POTENT NEUROKININ-1 ANTAGONIST ON NOCICEPTIVE TRANSMISSION IN THE RAT SPINAL-CORD", Neuroscience letters, 157(2), 1993, pp. 149-152

Abstract

The effect of intrathecal application of the selective neurokinin 1 (NK1) receptor antagonist RP67580 and its enantiomer RP68651 was studied on the responses of dorsal horn nociceptive neurones to formalin in the rat. The first and second phases of the formalin response were inhibited by RP67580 in a dose-related manner (1-10 mug), whereas RP68651(5 mug) facilitated the second phase of the response. The same doses of RP67580 had minimal effects on the acute C-fibre responses. The NK1receptor appears to play a role in prolonged nociceptive transmissionin the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:21:15