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Titolo:
CROSS-SECTIONAL STUDY OF PERIPHERAL MICROCIRCULATION IN DIABETIC-PATIENTS WITH MICROANGIOPATHY - INFLUENCE OF PANCREATIC AND KIDNEY-TRANSPLANTATION
Autore:
GFESSER M; NUSSER J; MULLERFELBER W; ABENDROTH D; LAND W; LANDGRAF R;
Indirizzi:
UNIV MUNICH,DEPT INTERNAL MED INNENSTADT,ZIEMSSENSTR 1 W-8000 MUNICH 2 GERMANY UNIV MUNICH,DEPT INTERNAL MED INNENSTADT,ZIEMSSENSTR 1 W-8000 MUNICH 2 GERMANY UNIV MUNICH,CTR TRANSPLANTAT W-8000 MUNICH 2 GERMANY
Titolo Testata:
Acta diabetologica
fascicolo: 2, volume: 30, anno: 1993,
pagine: 79 - 84
SICI:
0940-5429(1993)30:2<79:CSOPMI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS OXYGEN-TENSION; BLOOD-FLOW; AUTONOMIC NEUROPATHY; HEART-RATE; FOOT; SKIN; MELLITUS; FEET; TERM; CALCIFICATION;
Keywords:
AUTONOMIC NEUROPATHY; PANCREAS KIDNEY TRANSPLANTATION; PERIPHERAL MICROCIRCULATION; TRANSCUTANEOUS OXYGEN TENSION MEASUREMENT; VENOARTERIOLAR REFLEX; DIABETES-MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
M. Gfesser et al., "CROSS-SECTIONAL STUDY OF PERIPHERAL MICROCIRCULATION IN DIABETIC-PATIENTS WITH MICROANGIOPATHY - INFLUENCE OF PANCREATIC AND KIDNEY-TRANSPLANTATION", Acta diabetologica, 30(2), 1993, pp. 79-84

Abstract

Diabetic vascular lesions and peripheral autonomic neuropathy are both closely linked to long-term metabolic control of diabetes. Transcutaneous oxygen tension (P(tc)O2) measurements were made to elucidate whether autonomic neuropathy disturbs the cutaneous microcirculatory blood flow, and whether long-term glucose normalization ameliorates such impairment. Twenty-eight type 1 (insulin-dependent) diabetic patients in whom clinically significant macroangiopathy had been excluded by angiography were studied, subdivided into group A (n = 14; before simultaneous pancreas/kidney transplantation (SPKT); mean age 35 years, range22-51 years; mean duration of diabetes 24 years, (range 15-32) years and group B (n = 14; mean 31 months, range 2-101 months, after successful SPKT; mean age 35 years, range 19-56 years; mean duration of diabetes 22 years, range 14-29 years). On addition there was a group (groupC) of age- and sex-matched healthy control subjects (n = 14; mean age35 years, range 23-62 years). P(tc)O2 measurements included basal recordings at 44-degrees-C on the leg and the foot, functional recordingsat 44-degrees-C after arterial occlusion of the limb for 4 min, measurements during breathing 51 oxygen per minute and finally while standing up (stand up dP50/dt). All subjects underwent extensive cardiac autonomic testing. In this cross-sectional study the recordings of basal values and of the functional parameters after arterial occlusion and during breathing oxygen did not differ significantly between groups A, B and C. The stand-up dP50/dt values were not significantly different between groups A and B (0.43 +/- 0.02 vs 0.47 +/- 0.03 mmHg/s, mean + SEM); but A + B values were significantly higher than in C (0.22 +/- 0.01 mmHg/s; P<0.001). These values were correlated significantly with all parameters of cardiac autonomic neuropathy (r range-0.56 to -0.88;P<0.001). It may be concluded that normalization of blood glucose by pancreatic transplantation is not able to ameliorate peripheral microcirculation, but that measurement of transcutaneous oxygen tension is apossible new technique for quantifying alterations in the venoarteriolar reflex in peripheral diabetic autonomic neuropathy that lead to disturbed peripheral microcirculation in diabetic patients.

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Documento generato il 30/10/20 alle ore 23:48:05