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Titolo:
WHITE-MATTER CHANGES IN HEALTHY ELDERLY PERSONS CORRELATE WITH ATTENTION AND SPEED OF MENTAL PROCESSING
Autore:
YLIKOSKI R; YLIKOSKI A; ERKINJUNTTI T; SULKAVA R; RAININKO R; TILVIS R;
Indirizzi:
UNIV HELSINKI,DEPT NEUROL,MEMORY RES UNIT SF-00290 HELSINKI 29 FINLAND UNIV WESTERN ONTARIO,DEPT CLIN NEUROL SCI LONDON N6A 3K7 ONTARIO CANADA JOHN P ROBARTS RES INST LONDON ON CANADA UNIV HELSINKI,DEPT PSYCHOL SF-00100 HELSINKI 10 FINLAND UNIV HELSINKI,DEPT RADIOL SF-00100 HELSINKI 10 FINLAND UNIV HELSINKI,DEPT GERIATR SF-00100 HELSINKI 10 FINLAND
Titolo Testata:
Archives of neurology
fascicolo: 8, volume: 50, anno: 1993,
pagine: 818 - 824
SICI:
0003-9942(1993)50:8<818:WCIHEP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR SIGNAL ABNORMALITIES; LEUKO-ARAIOSIS; PATHOLOGICAL CORRELATION; ALZHEIMERS DEMENTIA; VASCULAR DEMENTIA; RISK-FACTORS; AGING BRAIN; LESIONS; ATROPHY; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
R. Ylikoski et al., "WHITE-MATTER CHANGES IN HEALTHY ELDERLY PERSONS CORRELATE WITH ATTENTION AND SPEED OF MENTAL PROCESSING", Archives of neurology, 50(8), 1993, pp. 818-824

Abstract

Objective.-To evaluate the association between white matter changes (leukoaraiosis [LA]) seen on magnetic resonance imaging and cognitive functions. Design.-Survey of cohorts of neurologically healthy elderly subjects derived consecutively from a population-based random sample. Setting.-General community, the Helsinki (Finland) Aging Brain Study. Subjects.-Cohorts of neurologically healthy subjects aged 55, 60, 65, 70, 75, 80, and 85 years (n=20,18,19,18, 1 7, 1 7, and 11 subjects, respectively; total N=120). Measures.-Leukoaraiosis was rated in the periventricular areas (0 to 24) and the centrum semiovale (0 to 24); also, a total LA score was obtained (0 to 48). The neuropsychological testbattery covered memory, verbal intellectual and constructional functions, language, speed and attention, and speed of mental processing, aswell as simple psychomotor speed. Results.-Low age-related LA scores and deterioration of cognitive functions were obtained in the normal subjects. When controlling for age, we found that speed and attention, together with the speed of mental processing measured by the Trail Making A and the Stroop tests, correlated with the total LA score. However, there was wide variation between subjects. Comparing groups with and without LA proved the association of LA with Trail Making A time, Stroop test result (words/time and difference/time), and the compound score of speed and attention. Presence of periventricular LA was especially related to speed of mental processing. Conclusion.-Leukoaraiosis could explain some of the intellectual impairment in the elderly, especially that of slowing of distinct motor and attentional functions, as well as slowing of mental processing. Mild LA in normal aged subjects could also signal brain at risk for further cognitive impairment.

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Documento generato il 30/11/20 alle ore 10:08:51