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Titolo:
DIFFERENTIAL RESPONSES TO CHALLENGE WITH LIVE AND DEAD MYCOBACTERIUM-BOVIS BACILLUS-CALMETTE-GUERIN
Autore:
CHAMBERS MA; MARSHALL BG; WANGOO A; BUNE A; COOK HT; SHAW RJ; YOUNG DB;
Indirizzi:
CENT VET LAB,DEPT BACTERIOL,MOL GENET UNIT,NEW HAW ADDLESTONE KT15 3NB SURREY ENGLAND ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT MED MICROBIOL LONDON W2 1PG ENGLAND ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT RESP MED LONDON W2 1PG ENGLAND ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT HISTOPATHOL LONDON W2 1PG ENGLAND
Titolo Testata:
The Journal of immunology
fascicolo: 4, volume: 158, anno: 1997,
pagine: 1742 - 1748
SICI:
0022-1767(1997)158:4<1742:DRTCWL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; NATURAL-KILLER-CELLS; MONOCLONAL-ANTIBODY NLDC-145; EXPERIMENTAL PULMONARY GRANULOMA; DENDRITIC CELLS; LEISHMANIA-MAJOR; GAMMA-INTERFERON; FACTOR-ALPHA; EXTRACELLULAR PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Chambers et al., "DIFFERENTIAL RESPONSES TO CHALLENGE WITH LIVE AND DEAD MYCOBACTERIUM-BOVIS BACILLUS-CALMETTE-GUERIN", The Journal of immunology, 158(4), 1997, pp. 1742-1748

Abstract

Bacillus Calmette-Guerin (BCG) vaccination has been shown to protect against challenge with virulent Mycobacterium tuberculosis in a range of experimental animal models: in each case, protective efficacy requires vaccination with live bacteria. With the goal of moving to a new generation of safer, nonliving vaccines, efforts have been made to identify the factors that determine the efficacy of live vaccination. We show that injection of live, but not dead, BCG induces localized swelling in the mouse footpad model. Live and dead bacteria induce similar responses during the first week after vaccination as determined by immunohistochemical analysis of the site of injection and of the draining lymph node. The subsequent differential response is characterized by migration of acid-fast bacilli to the draining lymph node in the case of the live vaccine. This is accompanied by an increase in mononuclear cells in the lymph node and by expression of inducible nitric oxide synthase (iNOS) both in the lymph node and at the site of injection. Theability of the bacteria to migrate to the lymph node may be an important element in the efficacy of live BCG vaccination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 11:17:57