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Titolo:
PROLACTIN RESPONSE TO ZOTEPINE IN SCHIZOPHRENIC-PATIENTS
Autore:
OTANI K; KONDO T; ISHIDA M; SASA H; HIGUCHI H; KANEKO S; FUKUSHIMA Y;
Indirizzi:
HIROSAKI UNIV,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN AKITA UNIV HOSP,DEPT PSYCHIAT AKITA JAPAN
Titolo Testata:
Human psychopharmacology
fascicolo: 1, volume: 8, anno: 1993,
pagine: 35 - 39
SICI:
0885-6222(1993)8:1<35:PRTZIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; CLINICAL-RESPONSE; NEUROLEPTIC DRUG; HALOPERIDOL; SERUM; CHLORPROMAZINE; SYMPTOMS;
Keywords:
ZOTEPINE; DOPAMINE; SEROTONIN; PROLACTIN; SERUM CONCENTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Otani et al., "PROLACTIN RESPONSE TO ZOTEPINE IN SCHIZOPHRENIC-PATIENTS", Human psychopharmacology, 8(1), 1993, pp. 35-39

Abstract

The prolactin response to an antipsychotic drug zotepine, which has both antidopaminergic and antiserotonergic effects, was studied in 24 inpatients suffering from schizophrenia. The daily dose was 100 mg in the first week, and 200 mg for the next three weeks. The mean serum concentrations of prolactin at the daily dose of 200 mg, but not 100 mg, were significantly higher than that before treatment. The DELTA prolactin (the change from the pretreatment concentration) was significantlycorrelated with zotepine concentrations at each week. At low zotepineconcentrations, patients with high pre-treatment prolactin concentrations showed negative DELTA prolactin. The present study thus suggests that at high concentrations zotepine shows predominantly antidopaminergic effects, while at low concentrations its antiserotonergic effects are predominant and/or it acts as a dopamine agonist.

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Documento generato il 19/01/20 alle ore 06:51:27