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Titolo:
TARGETED DISRUPTION OF IRF-1 OR IRF-2 RESULTS IN ABNORMAL TYPE-I IFN GENE INDUCTION AND ABERRANT LYMPHOCYTE DEVELOPMENT
Autore:
MATSUYAMA T; KIMURA T; KITAGAWA M; PFEFFER K; KAWAKAMI T; WATANABE N; KUNDIG TM; AMAKAWA R; KISHIHARA K; WAKEHAM A; POTTER J; FURLONGER CL; NARENDRAN A; SUZUKI H; OHASHI PS; PAIGE CJ; TANIGUCHI T; MAK TW;
Indirizzi:
UNIV TORONTO,DEPT IMMUNOL & MED BIOPHYS,AMGEN INST TORONTO M4X 1K9 ONTARIO CANADA UNIV TORONTO,DEPT IMMUNOL & MED BIOPHYS,ONTARIO CANC INST TORONTO M4X1K9 ONTARIO CANADA OSAKA UNIV,INST MOLEC & CELLULAR BIOL SUITA OSAKA 565 JAPAN
Titolo Testata:
Cell
fascicolo: 1, volume: 75, anno: 1993,
pagine: 83 - 97
SICI:
0092-8674(1993)75:1<83:TDOIOI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-BETA GENE; REGULATORY FACTOR-I; MEDIATE VIRUS INDUCIBILITY; T-CELLS; TRANSCRIPTIONAL ACTIVATOR; SIGNAL TRANSDUCTION; TRANSGENIC MICE; STEM-CELLS; EXPRESSION; MURINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
T. Matsuyama et al., "TARGETED DISRUPTION OF IRF-1 OR IRF-2 RESULTS IN ABNORMAL TYPE-I IFN GENE INDUCTION AND ABERRANT LYMPHOCYTE DEVELOPMENT", Cell, 75(1), 1993, pp. 83-97

Abstract

Interferon regulatory factor 1 (IRF-1), a transcriptional activator, and its antagonistic repressor, IRF-2, were originally identified as regulators of the type I interferon (IFN) system. We have generated mice deficient in either IRF-1 or IRF-2 by gene targeting in embryonic stem cells. IRF-1-deficient fibroblasts lacked the normally observed type I IFN induction by poly(I):poly(C), while they induced type I IFN tosimilar levels as the wild type following Newcastle disease virus (NDV) infection. In contrast, IRF-2-deficient fibroblasts showed up-regulated type I IFN induction by NDV infection. A profound reduction of TCRalphabeta+CD4-CD8+ T cells in IRF-1-deficient mice, with a thymocyte developmental defect, reveals a critical role for IRF-1 in T cell development. IRF-2-deficient mice exhibited bone marrow suppression of hematopoiesis and B lymphopoiesis and mortality following lymphocytic choriomeningitis virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:48:41