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Titolo:
QUANTITATIVE BLOOD-FLOW MEASUREMENT OF SKELETAL-MUSCLE USING OXYGEN-15-WATER AND PET
Autore:
RUOTSALAINEN U; RAITAKARI M; NUUTILA P; OIKONEN V; SIPILA H; TERAS M; KNUUTI MJ; BLOOMFIELD PM; IIDA H;
Indirizzi:
TURKU PET CTR,KIINAMYLLYNKATU 4-6 FIN-20520 TURKU FINLAND UNIV TURKU,DEPT MED & NUCL MED TURKU FINLAND MRC,CYCLOTRON UNIT LONDON ENGLAND RES INST BRAIN & BLOOD VESSELS,DEPT RADIOL & NUCL MED AKITA JAPAN
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 2, volume: 38, anno: 1997,
pagine: 314 - 319
SICI:
0161-5505(1997)38:2<314:QBMOSU>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; SENSITIVITY; (H2O)-O-15; MECHANISM; INSULIN; WATER; MODEL; O-15;
Keywords:
PET; MUSCLE BLOOD FLOW; LOW FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
U. Ruotsalainen et al., "QUANTITATIVE BLOOD-FLOW MEASUREMENT OF SKELETAL-MUSCLE USING OXYGEN-15-WATER AND PET", The Journal of nuclear medicine, 38(2), 1997, pp. 314-319

Abstract

The aim of the present study was to evaluate quantitation of muscle blood flow using [(50)]H2O and PET, Methods: The autoradiographic (ARG)and the steady-state methods using PET were used to measure femoral muscle blood flow, A simulation study was performed to examine the errors due to contamination of radioactivity in the blood content in muscle tissue, statistical noise and delay and the dispersion of the input curve in the ARG method, Five separate paired muscle blood flow examinations were carried out for comparison of the ARG and the steady-statetechniques, including measurement of muscle blood volume in each subject. To obtain the normal range for resting muscle blood flow, additional measurements with the ARG method were performed in 16 normal subjects, Results: When the integration time in ARG was increased to 200-300 sec, the errors due to arterial blood volume, statistical noise, delay and dispersion of the input curve were significantly reduced, Muscle blood flow values in the ARG (200 sec) and the steady-state studies were in good agreement, and each provided an estimated accuracy of 5%,Resting muscle blood flow averaged 3.12 +/- 1.55 ml/min . 100 g muscle (range 1.43-6.72 ml/min . 100 g muscle, n = 18), Conclusion: The ARGand the steady-state methods provided consistent blood flow values far skeletal muscle when a long tissue integration time (greater than orequal to 200 sec) was applied in the ARG study, Based on the lower effective radiation dose and the shorter total scan duration, the ARG method is favored over the steady-state method in the measurement of muscle blood flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:24:59