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Titolo:
EFFECT OF HALOPERIDOL DOSE ON IODINE-123-IBZM BRAIN SPECT IMAGING IN SCHIZOPHRENIC-PATIENTS
Autore:
VALLABHAJOSULA S; HIRSCHOWITZ J; MACHAC J;
Indirizzi:
MT SINAI MED CTR,DIV NUCL MED,DEPT RADIOL NEW YORK NY 10029 MT SINAI MED CTR,DEPT PSYCHIAT NEW YORK NY 10029 BRONX VET ADM MED CTR NEW YORK NY 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 2, volume: 38, anno: 1997,
pagine: 203 - 207
SICI:
0161-5505(1997)38:2<203:EOHDOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; I-123 IBZM; EMISSION TOMOGRAPHY; DOPAMINE-RECEPTORS; NEUROLEPTICS; CLOZAPINE; BINDING; DRUGS; AGENT;
Keywords:
IODINE-123-IBZM; RECEPTOR IMAGING; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
S. Vallabhajosula et al., "EFFECT OF HALOPERIDOL DOSE ON IODINE-123-IBZM BRAIN SPECT IMAGING IN SCHIZOPHRENIC-PATIENTS", The Journal of nuclear medicine, 38(2), 1997, pp. 203-207

Abstract

Studies have suggested that antipsychotic drug therapy with haloperidol in schizophrenic patients requires an optimal dose that blocks the brain dopamine D2 receptors. We evaluated the effect of different doses of haloperidol on D2 receptor occupancy in schizophrenia. Methods: Three normal subjects and three patients with acute schizophrenia had serial brain SPECT imaging studies (every 5 min) for 3 hr following theinjection of [I-123]IBZM. The patients had IBZM studies off medication and at different doses (1-10 mg) of haloperidol. Results: The basal ganglia (BG) were well visualized in normals and in schizophrenics offmedication. After haloperidol therapy, SPECT images showed qualitatively diminished activity in the basal ganglia. ROIs were drawn over thebasal ganglia and cerebellum (CE). The results were expressed as BG/CE ratios. At 2 hr postinjection of IBZM, the mean BG/CE ratio in normals was 1.75 +/- 0.025. In schizophrenics, the BG/CE ratio off medication was 1.54 +/- 0.12. The BC/CE ratio showed an inverse relationship to haloperidol dose; 1.46 at 1 mg, 1.25 at 4 mg and 1.05 at 10 mg, respectively. Conclusion: These results demonstrate that IBZM brain SPECT imaging studies are potentially useful to relate the antipsychotic drug D2 receptor occupancy with the administered dose in schizophrenic patients and may ultimately help optimize antipsychotic treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:27:06