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Titolo:
REGIONAL CEREBRAL BLOOD-FLOW AND NEGATIVE POSITIVE SYMPTOMS IN 24 DRUG-NAIVE SCHIZOPHRENICS
Autore:
SABRI O; ERKWOH R; SCHRECKENBERGER M; CREMERIUS U; SCHULZ G; DICKMANN C; KAISER HJ; STEINMEYER EM; SASS H; BUELL U;
Indirizzi:
RHEIN WESTFAL TH AACHEN,DEPT NUCL MED,PAUWELSSTR 30 D-52057 AACHEN GERMANY RHEIN WESTFAL TH AACHEN,DEPT NUCL MED AACHEN GERMANY RHEIN WESTFAL TH AACHEN,DEPT PSYCHIAT AACHEN GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 2, volume: 38, anno: 1997,
pagine: 181 - 188
SICI:
0161-5505(1997)38:2<181:RCBANP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; COMPUTED-TOMOGRAPHY; HYPOFRONTALITY; ABNORMALITIES; PATTERNS; PET;
Keywords:
SCHIZOPHRENIA; TECHNETIUM-99M-HMPAO; SPECT; NEUROLEPTIC TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
O. Sabri et al., "REGIONAL CEREBRAL BLOOD-FLOW AND NEGATIVE POSITIVE SYMPTOMS IN 24 DRUG-NAIVE SCHIZOPHRENICS", The Journal of nuclear medicine, 38(2), 1997, pp. 181-188

Abstract

SPECT/PET studies in schizophrenia revealed inconsistent changes of regional cerebral blood flow (rCBF). Frontal hyperperfusion as well as hypoperfusion are described. This study was undertaken to investigate the relations between rCBF, psychopathology according to PANSS and effects of neuroleptic therapy. Methods: Twenty-four drug-naive acute patients with a first manifestation of schizophrenia were examined with Tc-99m-HMPAO brain SPECT and assessed according to PANSS. Of these, 22 were controlled again after neuroleptic treatment. Following attenuation correction, region-to-cerebellar count ratios were obtained from 98irregular regions of interest drawn in all slices (6.25 mm). The ratios were compared to 20 control subjects, and changes lying outside of 2 s.d. were considered abnormal. Results. In different drug-naive patients, hyperperfusion as well as hypoperfused patterns were found. In drug-naive patients, the seven subscores of positive symptoms (pos 1-7)in PANSS showed different correlations to rCBF: Formal thought disorders (pos 2) and grandiosity (pos 5) were positively correlated to bifrontal and bitemporal rCBF (r = +0.59 to +0.70). Delusional ideas (pos 1), hallucinatory behavior (pos 3) and suspiciousness (pos 6) demonstrated a negative correlation to bifrontal, cingulate, left temporal andleft thalamic rCBF (r = -0.59 to -0.66). Stereotyped ideas (neg 7) asa negative symptom showed a negative correlation to left frontal, left temporal and left parietal rCBF (r = -0.59 to -0.65). No correlations were found between residual positive symptoms and rCBF after neuroleptic treatment and clinical improvement, but all negative symptoms (neg 1-7) had a negative correlation to bifrontal, bitemporal, cingulate,basal ganglia and thalamic rCBF (r = -0.59 to -0.74). Conclusion: Ourresults illustrate that different positive symptoms are accompanied by different rCBF values: some induce hyperperfusion, others hypoperfusion. After therapy (and reduction of positive symptoms), only negativesymptoms correlate exclusively to hypoperfusion. This may be the crucial factor in explaining inconsistencies of past results in perfusion pattern in drug-naive schizophrenic patients.

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Documento generato il 27/01/20 alle ore 01:28:06