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Titolo:
MECHANICAL STIMULATION AND CAPSAICIN-EVOKED VASODILATION BY PARASYMPATHETIC REFLEX MECHANISMS IN THE PIG NASAL-MUCOSA
Autore:
STJARNE P; LUNDBLAD L; LUNDBERG JM;
Indirizzi:
KAROLINSKA HOSP,DEPT OTORHINOLARYNGOL S-10401 STOCKHOLM 60 SWEDEN KAROLINSKA INST,DEPT PHARMACOL S-10401 STOCKHOLM 60 SWEDEN
Titolo Testata:
Acta oto-laryngologica
fascicolo: 5, volume: 113, anno: 1993,
pagine: 649 - 654
SICI:
0001-6489(1993)113:5<649:MSACVB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; CO-EXISTENCE; SUBSTANCE-P; BLOOD-FLOW; SECRETION; RELEASE; TACHYKININS; NICOTINE; NERVES;
Keywords:
NASAL MUCOSA; MECHANICAL STIMULATION; CAPSAICIN; BILATERAL VASODILATION; PARASYMPATHETIC; NONCHOLINERGIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Stjarne et al., "MECHANICAL STIMULATION AND CAPSAICIN-EVOKED VASODILATION BY PARASYMPATHETIC REFLEX MECHANISMS IN THE PIG NASAL-MUCOSA", Acta oto-laryngologica, 113(5), 1993, pp. 649-654

Abstract

A model was developed using pentobarbital anesthetized pigs to study bilateral blood flow changes in the nasal mucosa by flow-probes on both sphenopalatine arteries. Unilateral mechanical stimulation of the nasal mucosa for 10 s as well as close intra-arterial capsaicin infusioninduced bilateral vasodilation. The magnitude of the vasodilator responses were similar on both sides, although the capsaicin effect (maximal increase in arterial blood flow by about 100 ml/min) was larger than that of the mechanical stimulation. Pretreatment with atropine (0.5 mg x kg-1) had no effect on the vascular responses to capsaicin or mechanical stimulation. However, when the pigs were pretreated with the ganglionic nicotinic receptor blocking agent, chlorisondamine (3 mg x kg-1), the vasodilatory responses to mechanical stimulation were abolished and the responses to capsaicin infusion markedly reduced (90-95%). These data indicate that unilateral mechanical stimulation as well ascapsaicin infusion evoke bilateral nasal vasodilation which is probably mediated via a central reflex arch with a parasympathetic non-cholinergic final step.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:30:58