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Titolo:
MIDKINE THAT PROMOTES SURVIVAL OF FETAL HUMAN NEURONS IS PRODUCED BY FETAL HUMAN ASTROCYTES IN CULTURE
Autore:
SATOH J; MURAMATSU H; MORETTO G; MURAMATSU T; CHANG HJ; KIM ST; CHO JM; KIM SU;
Indirizzi:
UNIV BRITISH COLUMBIA HOSP,DEPT MED,DIV NEUROL,2211 WESBROOK MALL VANCOUVER V6T 2B5 BC CANADA UNIV BRITISH COLUMBIA HOSP,DEPT MED,DIV NEUROL,2211 WESBROOK MALL VANCOUVER V6T 2B5 BC CANADA LUCKY BIOTECH CORP EMERYVILLE CA 00000 KAGOSHIMA UNIV,FAC MED,DEPT BIOCHEM KAGOSHIMA 890 JAPAN
Titolo Testata:
Developmental brain research
fascicolo: 2, volume: 75, anno: 1993,
pagine: 201 - 205
SICI:
0165-3806(1993)75:2<201:MTPSOF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONAL CARCINOMA-CELLS; ACID-RESPONSIVE GENE; FIBROBLAST GROWTH-FACTOR; HEPARIN-BINDING-FACTORS; MOUSE EMBRYOGENESIS; TERATOCARCINOMA SYSTEM; MK; DIFFERENTIATION; EXPRESSION; PROTEIN;
Keywords:
FETAL HUMAN ASTROCYTE; FETAL HUMAN NEURON; IMMUNOBLOTTING; MIDKINE; NEUROTROPHIC EFFECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J. Satoh et al., "MIDKINE THAT PROMOTES SURVIVAL OF FETAL HUMAN NEURONS IS PRODUCED BY FETAL HUMAN ASTROCYTES IN CULTURE", Developmental brain research, 75(2), 1993, pp. 201-205

Abstract

Midkine (MK), a retinoic acid responsive gene product, is a novel heparin-binding growth factor with an apparent molecular weight of 14-kDa. In fetal human neuron cultures, addition of recombinant human MK (10-100 ng/ml) resulted in a 3-fold increase in the number of surviving neurons under the serum-free culture condition. Production of MK was identified in the conditioned medium of astrocyte-enriched cultures by imunoblotting but not in the medium of neuron-enriched cultures. The level of MK production was not affected by treatment with retinoic acid. These results indicate that in the developing human central nervous system, astrocytes secrete MK that exhibits potent trophic activity to neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:28:41