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Titolo:
INHALED NEDOCROMIL SODIUM REDUCES HISTAMINE-RELEASE FROM ISOLATED LARGE AIRWAY SEGMENTS OF ASTHMATIC SUBJECTS IN-VIVO
Autore:
MAXWELL DL; HAWKSWORTH RJ; LEE TH;
Indirizzi:
UMDS,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,HUNTS HOUSE,ST THOMAS ST LONDON SE1 9RT ENGLAND UMDS,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,HUNTS HOUSE,ST THOMAS ST LONDON SE1 9RT ENGLAND
Titolo Testata:
The European respiratory journal
fascicolo: 8, volume: 6, anno: 1993,
pagine: 1145 - 1150
SICI:
0903-1936(1993)6:8<1145:INSRHF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; MAST-CELLS; INDUCED BRONCHOCONSTRICTION; MEDIATORS; HYPEROSMOLAR; CROMOGLYCATE; GENERATION; INHIBITION; BASOPHILS; PGD2;
Keywords:
ASTHMA; BRONCHOSCOPY; ENDOGENOUS HISTAMINE; HYPEROSMOLAR CHALLENGE; NEDOCROMIL SODIUM; PROSTAGLANDIN-D2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Maxwell et al., "INHALED NEDOCROMIL SODIUM REDUCES HISTAMINE-RELEASE FROM ISOLATED LARGE AIRWAY SEGMENTS OF ASTHMATIC SUBJECTS IN-VIVO", The European respiratory journal, 6(8), 1993, pp. 1145-1150

Abstract

Placement of an intrabronchial single balloon catheter provides the possibility of measuring histamine release in isolated large airway segments in vivo. We wanted to assess the protective effect of nedocromilsodium on intrabronchial histamine release after hyperosmolar challenge. Six mild asthmatics were bronchoscoped 30 min after inhalation of 4 mg nedocromil sodium or placebo, given via a metered dose inhaler ina randomized, double-blind, cross-over study. Lavage of the left mainbronchus was carried out proximal to a balloon catheter inflated at its bifurcation, and specimens were assayed for histamine and prostaglandin D2 (PGD2) by radioimmunoassay. The rise in histamine concentration in bronchial epithelial fluid following hyperosmolar saline challenge was significantly greater following placebo than following nedocromil sodium (mean+/-SEM prechallenge histamine concentration on placebo day 6.9+/-2.9 nM; post-challenge: 25.3+/-8.0 nM; mean+/-SEM prechallenge histamine concentration on the day nedocromil sodium was given: 3.7+/-0.7 nM; post-challenge 5.8+/-1.7 nM). Changes in PGD2 levels reflected the changes in histamine, but the variability of response was large, and there were no significant differences between the effects of placebo and nedocromil sodium. The procedure caused significantly greaterfalls in peak expiratory now rates following placebo (mean+/-SEM percentage fall 20.2+/-4.4%) than following nedocromil sodium (0.9+/-5.8%,p<0.02). We conclude that there is tonic basal histamine release within asthmatic airways, and that nedocromil sodium inhibits histamine release from mediator cells in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:09:11