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Titolo:
BROMINE-76-METABROMOBENZYLGUANIDINE - A PET RADIOTRACER FOR MAPPING SYMPATHETIC-NERVES OF THE HEART
Autore:
VALETTE H; LOCH C; MARDON K; BENDRIEM B; MERLET P; FUSEAU C; SABRY S; RAFFEL D; MAZIERE B; SYROTA A;
Indirizzi:
SERV HOSP FREDERIC JOLIOT,DRIPP,CEA,4 PL GEN LECLERC F-91401 ORSAY FRANCE
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 34, anno: 1993,
pagine: 1739 - 1744
SICI:
0161-5505(1993)34:10<1739:B-APRF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCINTIGRAPHIC ASSESSMENT; ADRENERGIC-INNERVATION; METAIODOBENZYLGUANIDINE; NOREPINEPHRINE; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H. Valette et al., "BROMINE-76-METABROMOBENZYLGUANIDINE - A PET RADIOTRACER FOR MAPPING SYMPATHETIC-NERVES OF THE HEART", The Journal of nuclear medicine, 34(10), 1993, pp. 1739-1744

Abstract

Iodine-123-metaiodobenzylguanidine (MIBG) is used to qualitatively assess heart innervation with single-photon emission computed tomography(SPECT). This approach is clinically useful in the prognostic evaluation of congestive heart failure. To improve quantification of uptake of the tracer using positron emission tomography (PET), we studied the characteristics of the bromoanalog of MIBG. Bromine-76-metabromobenzylguanidine (Br-76-MBBG) was prepared from a heteroisotopic exchange between radioactive bromine atoms (noncarrier-added (Br-76) BrNH4) and the cold iodine atoms of the precursor metaiodobenzylguanidine. Biodistribution was studied in rats and PET cardiac imaging performed in dogs. Myocardial uptake was high and prolonged in both species (mean half-life in dogs: 580 min). In rats, myocardial uptake was inhibited by desipramine by 64%, whereas after pretreatment with 6-hydroxydopamine uptake was reduced by 84%. In dogs pretreated with 6-hydroxydopamine or with desipramine, a steep washout of the tracer occurred (mean half-life: 136 min and 118 min, respectively). The nonspecific uptake plus thepassive neuronal diffusion of the tracer could be estimated at about 25%-30% of the total fixation. In dogs, analysis of unchanged Br-76-MBBG in plasma showed that radiotracer metabolism was slow: 60 min afterinjection, 80% of the radioactivity was related to unchanged Br-76-MBBG. These preliminary findings suggest that Br-76-MBBG could be used to quantitatively assess adrenergic innervation in heart disease using PET. When combined with use of C-11-CGP 12177, cardiac adrenergic neurotransmission can be assessed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:58:56