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Titolo:
TIME-COURSE OF THE CHANGES IN PREDNISOLONE PHARMACOKINETICS AFTER COADMINISTRATION OR DISCONTINUATION OF RIFAMPIN
Autore:
LEE KH; SHIN JG; CHONG WS; KIM S; LEE JS; JANG IJ; SHIN SG;
Indirizzi:
SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL,28 YONGON DONG SEOUL 110799 SOUTH KOREA SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL,28 YONGON DONG SEOUL 110799 SOUTH KOREA INJE UNIV,COLL MED,DEPT PHARMACOL PUSAN SOUTH KOREA SEOUL NATL UNIV,DEPT CLIN PHARMACOL SEOUL 151 SOUTH KOREA SEOUL NATL UNIV,DEPT INTERNAL MED SEOUL 151 SOUTH KOREA
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 3, volume: 45, anno: 1993,
pagine: 287 - 289
SICI:
0031-6970(1993)45:3<287:TOTCIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOAVAILABILITY;
Keywords:
PREDNISOLONE; RIFAMPIN; DRUG-INTERACTION; PHARMACOKINETICS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Lee et al., "TIME-COURSE OF THE CHANGES IN PREDNISOLONE PHARMACOKINETICS AFTER COADMINISTRATION OR DISCONTINUATION OF RIFAMPIN", European Journal of Clinical Pharmacology, 45(3), 1993, pp. 287-289

Abstract

We have investigated changes in the pharmacokinetics of prednisolone caused by co-administration or discontinuation of rifampin. Serial IV pharmacokinetic studies of prednisolone (1 mg/kg) in groups of 3 patients over a 1 month period of rifampin co-treatment or after its withdrawal, revealed significant changes in the area under the curve, the total clearance, the non-renal clearance and the half-life. The changes in the pharmacokinetic parameters reached a 1.5 to 2-fold plateau after 2 weeks and the half maximal effect was attained within 5 days. Neither the volume of distribution nor the protein binding of prednisolonewere significantly altered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:58:26