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Titolo:
CHOLIC-ACID AND URSODEOXYCHOLIC ACID THERAPY IN PRIMARY BILIARY-CIRRHOSIS - CHANGES IN BILE-ACID PATTERNS AND THEIR CORRELATION WITH LIVER-FUNCTION
Autore:
GULDUTUNA S; LEUSCHNER M; WUNDERLICH N; NICKEL A; BHATTI S; HUBNER K; LEUSCHNER U;
Indirizzi:
JOHANN WOLFGANG GOETHE UNIV KLIN,ZENTRUM INNEREN MED,THEODOR STERN KAI 7 D-60596 FRANKFURT GERMANY UNIV FRANKFURT,CTR INTERNAL MED,DEPT GASTROENTEROL W-6000 FRANKFURT GERMANY UNIV FRANKFURT,CTR PATHOL W-6000 FRANKFURT GERMANY
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 3, volume: 45, anno: 1993,
pagine: 221 - 225
SICI:
0031-6970(1993)45:3<221:CAUATI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAUROCHOLATE-INDUCED CHOLESTASIS; CHENODEOXYCHOLIC ACID; GALLSTONE PATIENTS; LIPID SECRETION; METABOLISM; ABSORPTION; SALTS; RAT; TAUROURSODEOXYCHOLATE; HEPATOCYTES;
Keywords:
PRIMARY BILIARY CIRRHOSIS; URSODEOXYCHOLIC ACID THERAPY; CHOLIC ACID; ALPHA-DIHYDROXY BILE SALTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Guldutuna et al., "CHOLIC-ACID AND URSODEOXYCHOLIC ACID THERAPY IN PRIMARY BILIARY-CIRRHOSIS - CHANGES IN BILE-ACID PATTERNS AND THEIR CORRELATION WITH LIVER-FUNCTION", European Journal of Clinical Pharmacology, 45(3), 1993, pp. 221-225

Abstract

We treated 6 patients with Stage II primary biliary cirrhosis with cholic acid (CA) 10 mg . kg - 1 per day for 3 months and then with the same dose of ursodeoxycholic acid (UDCA). A matching group of 6 patients was observed for 3 months without any therapy. Liver function tests and serum and stool bile acids were investigated before, during and atthe end of CA and UDCA therapy. The results of liver function tests deteriorated after 6-8 weeks of CA therapy and the changes were correlated (r = 0.92) with an increase in alpha-dihydroxy-bile acids (chenodeoxycholic acid and deoxycholic acid) in the serum. The 24 h excretion of DCA in 24 h faeces was markedly increased. Ursodeoxycholic acid treatment improved liver function tests; after 4 weeks glutamate dehydrogenase (GLDH) had decreased. After 8-12 weeks of therapy ursodeoxycholic acid had increased to 50-60 % of the total serum bile acids whereas the more apolar bile acids were significantly decreased. No changes inliver function tests or bile acid metabolism were found in the untreated group. Since CA and UDCA are non-toxic in man, this trial indicates that the apolar bile acids chenodeoxycholic acid and deoxycholic acid may be responsible for the deterioration of liver function in primary biliary cirrhosis. However, the therapeutic effect of UDCA cannot beexplained merely by the decrease in alpha-dihydroxy-bile acids in theserum, since the laboratory results had improved prior to the decrease in the serum apolar bile acids.

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Documento generato il 30/11/20 alle ore 05:35:25