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Titolo:
HTLV-I MATERNAL TRANSMISSION IN MARTINIQUE, USING SEROLOGY AND POLYMERASE CHAIN-REACTION
Autore:
MONPLAISIR N; NEISSONVERNANT C; BOUILLOT M; DUCDODON M; UGARTE E; VALETTE I; DEZAPHY Y; OUKA M; EUDARIC MG; GAZZOLO L; LAROUZE B; DAURIOL L;
Indirizzi:
27 RUE MOUZAIA F-75019 PARIS FRANCE GENSET F-75011 PARIS FRANCE CTR TRANSFUS FORT DE FRANCE FORT DE FRANCE 97205 MARTINIQUE CHRU MARTINIQUE FORT DE FRANCE 97200 MARTINIQUE INSERM,U13,IMEA F-75109 PARIS FRANCE FAC MED ALEXIS CARREL,UCBL,CNRS,UMR 30 F-69372 LYON 08 FRANCE
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 9, volume: 9, anno: 1993,
pagine: 869 - 874
SICI:
0889-2229(1993)9:9<869:HMTIMU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LEUKEMIA; VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; BLOOD MONONUCLEAR-CELLS; CHILD TRANSMISSION; INFECTION; LYMPHOMA; AMPLIFICATION; ANTIBODY; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N. Monplaisir et al., "HTLV-I MATERNAL TRANSMISSION IN MARTINIQUE, USING SEROLOGY AND POLYMERASE CHAIN-REACTION", AIDS research and human retroviruses, 9(9), 1993, pp. 869-874

Abstract

We have investigated HTLV-I and HTLV-II infection in children born toHTLV-I-seropositive or indeterminate Western blot mothers in Martinique by using the polymerase chain reaction (PCR). Only HTLV-I and no HTLV-II-positive samples were found in this study. All the samples from HTLV-I-seropositive children and adults were PCR positive, whereas thefour HIV-I-seropositive and Western blot HTLV-I-negative mothers and their eight children were all PCR negative. Therefore, PCR and serology were in complete agreement in these patients. However, two of the six mothers who were first indeterminate by Western blot, and who later became seronegative, were found positive by PCR. Of the 27 children (ages 2-12 years), born to HTLV-I-seropositive and PCR-positive mothers,2 were seropositive and PCR positive, 5 were seronegative and PCR positive with 2 primer pairs in gag and pol, and 4 were seronegative and PCR positive with only 1 of the primer pairs. In contrast to an initial rate of transmission of 7% estimated by serology we found a rate of transmission of 28 to 41% (whether or not children who were positive with only one of the primer pairs were included). Thus, our study confirms that PCR is useful in detecting HTLV-I infection in children before seroconversion and underlines the potential lack of sensitivity of serology to detect contaminating HTLV-I blood units in endemic areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 08:44:38