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Titolo:
ANTIPLATETLET AND ANTITHROMBOTIC EFFECTS OF OP-41483-CENTER-DOT-ALPHA-CD, A PROSTACYCLIN ANALOG, IN EXPERIMENTAL-ANIMALS
Autore:
KATSUBE N; SAKAGUCHI K; FUJITANI B; AISHITA H;
Indirizzi:
ONO PHARMACEUT CO LTD,MINASE RES INST,SAKURAI 3-1-1 MISHIMA OSAKA 618JAPAN DAINIPPON PHARMACEUT CO LTD,EXPLORATORY RES LABS SUITA OSAKA 564 JAPAN
Titolo Testata:
Prostaglandins, leukotrienes and essential fatty acids
fascicolo: 4, volume: 49, anno: 1993,
pagine: 795 - 804
SICI:
0952-3278(1993)49:4<795:AAAEOO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-I2 ANALOG; CONTROLLED TRIAL; AGGREGATION; ARTERIAL; ADHESION; PGI2; SUBENDOTHELIUM; INHIBITOR; OP-41483; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
N. Katsube et al., "ANTIPLATETLET AND ANTITHROMBOTIC EFFECTS OF OP-41483-CENTER-DOT-ALPHA-CD, A PROSTACYCLIN ANALOG, IN EXPERIMENTAL-ANIMALS", Prostaglandins, leukotrienes and essential fatty acids, 49(4), 1993, pp. 795-804

Abstract

The effects of OP-41483.alpha-CD, 5(E)-6,9-deoxa-6,9 a-methylene-15-cyclopentyl-16,17,18,19,20-pentanor prostacyclin (PGI2).alpha-cyclodextrin clathrate, on platelet function and experimental thrombosis were studied. In human platelets, OP-41483 inhibited aggregation induced by adenosine diphosphate (ADP) or collagen, promoted disaggregation, and elevated cyclic adenosine monophosphate (cAMP) levels in vitro at the same order of concentrations. The equipotent antiaggregatory activity of OP-41483 to human platelets was observed in monkey platelets in vitro. Furthermore, intravenous administration of OP-41483 to monkeys, unlike PGI2, showed the antiaggregatory effect on platelets but with less effect on blood pressure, suggesting that a differential sensitivityto OP-41483 between platelet function and vascular tone exists in monkeys. In rabbits, OP-41483-alpha-CD attenuated platelet aggregation induced by ADP, collagen and platelet activating factor (PAF), decreasedcirculating platelet aggregates, and inhibited platelet adhesiveness to de-endothlialized blood vessels. These results suggest that the anti-thrombotic effects of OP-41483 are associated with its potent antiplatelet activities mainly because of the elevation of cAMP levels in the platelets. The potent anti-thrombotic and less hypotensive effects of this compound may be useful for various thrombotic disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:21:25