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Titolo:
ABNORMAL EMBRYOGENESIS IN THE ETIOLOGY OF ECTOPIC PREGNANCY
Autore:
KARIKOSKI R; AINE R; HEINONEN PK;
Indirizzi:
TAMPERE UNIV HOSP,DEPT PATHOL,POB 2000 SF-33520 TAMPERE FINLAND UNIV CENT HOSP TAMPERE,DEPT PATHOL TAMPERE FINLAND UNIV CENT HOSP TAMPERE,DEPT OBSTET & GYNAECOL TAMPERE FINLAND
Titolo Testata:
Gynecologic and obstetric investigation
fascicolo: 3, volume: 36, anno: 1993,
pagine: 158 - 162
SICI:
0378-7346(1993)36:3<158:AEITEO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARAFFIN-EMBEDDED TISSUE; DNA CONTENT; WASTAGE;
Keywords:
FLOW CYTOMETRY; ECTOPIC PREGNANCY; ANEUPLOIDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Karikoski et al., "ABNORMAL EMBRYOGENESIS IN THE ETIOLOGY OF ECTOPIC PREGNANCY", Gynecologic and obstetric investigation, 36(3), 1993, pp. 158-162

Abstract

Flow cytometric measurements of DNA using paraffin-embedded retrospective material were performed on 42 samples of ectopic conceptuses to see whether there were any aberrations from normal DNA. It was found that DNA aneuploidy was associated with tubal implantation in 14 (33%) cases. The range of DNA indices of the DNA aneuploid peaks was from 1.14 to 2.17. Near-diploid karyotype changes were seen in 8 (19%) cases. Six cases were found to be tetraploid. In 18 abortions with known cytogenetic status, all 3 cytogenetically normal cases showed DNA diploidyin flow cytometry. It was also found that 3 out of 10 cases of trisomy 21 were DNA aneuploid. Flow cytometric DNA reflects only chromosomalchanges where a significant number of cells have either lost or acquired several chromosomes. DNA aneuploidy of ectopic pregnancies suggests a grave chromosomal aberration in one third of the cases. Abnormal embryogenesis may contribute significantly to the occurrence of ectopicimplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:13:28