Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEUROTOXICOLOGIC EXAMINATION OF RATS EXPOSED TO 1,1,1-TRICHLOROETHANEVAPOR FOR 13 WEEKS
Autore:
MATTSSON JL; ALBEE RR; LOMAX LG; BEEKMAN MJ; SPENCER PJ;
Indirizzi:
DOW CHEM CO USA,HLTH & ENVIRONM SCI,1803 BLDG MIDLAND MI 48674
Titolo Testata:
Neurotoxicology and teratology
fascicolo: 5, volume: 15, anno: 1993,
pagine: 313 - 326
SICI:
0892-0362(1993)15:5<313:NEORET>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY-EVOKED-POTENTIALS; SUBCHRONIC NEUROTOXICITY; FISCHER-344 RATS; TOLUENE; DICHLOROMETHANE; INHALATION; BRAIN;
Keywords:
RATS; 1,1,1-TRICHLOROETHANE; SUBCHRONIC 1,1,1-T; EVOKED POTENTIALS; FUNCTIONAL OBSERVATIONAL BATTERY; NEUROPATHOLOGY; GRIP PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Mattsson et al., "NEUROTOXICOLOGIC EXAMINATION OF RATS EXPOSED TO 1,1,1-TRICHLOROETHANEVAPOR FOR 13 WEEKS", Neurotoxicology and teratology, 15(5), 1993, pp. 313-326

Abstract

Large evoked potential and EEG changes occurred in a pilot study in Fischer 344 rats during exposure to 2000 ppm of 1,1,1-trichloroethane (1,1,1-T; a cleaning solvent with anesthetic properties). In the main study, rats were evaluated for persistent nervous system effects the week following exposure to 0, 200, 630, or 2000 ppm 1,1,1-T for 6 h/day,5 days/week, for 13 weeks. Rats were clinically examined regularly and were given a functional observational battery monthly (FOB, including forelimb and hindlimb grip performance testing). After 13 weeks of exposure, the rats were evaluated by FOB and by visual, auditory, somatosensory, and caudal nerve-evoked potentials. After functional testing, a subgroup of rats had histopathologic examination of brain, spinal cord, peripheral nerves, and limb muscles. There were no post-exposuretreatment-related findings in any parameter (FOB observations plus 39dependent variables) except for a slightly smaller forelimb grip performance in the 2000-ppm exposure group. There was no recognized toxicologic significance for the difference in forelimb grip performance; a lack of findings in any other clinical, evoked potential or morphologic parameter did not support a diagnosis of neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:17:34