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Titolo:
AMANTADINE AND KETAMINE-INDUCED IMPROVEMENT OF MOTOR COORDINATION IN LURCHER MUTANT MICE
Autore:
LALONDE R; JOYAL CC; GUASTAVINO JM; COTE C; BOTEZ MI;
Indirizzi:
HOP HOTEL DIEU,NEUROL SERV,NEUROBIOL LAB MONTREAL H2W 1T8 PQ CANADA UNIV NANCY 1,BEHAV BIOL & PHYSIOL LAB F-54506 VANDOEUVRE NANCY FRANCE UNIV MONTREAL,DEPT MED MONTREAL H3C 3J7 QUEBEC CANADA UNIV MONTREAL,DEPT PSYCHOL MONTREAL H3C 3J7 QUEBEC CANADA
Titolo Testata:
Restorative neurology and neuroscience
fascicolo: 5-6, volume: 5, anno: 1993,
pagine: 367 - 370
SICI:
0922-6028(1993)5:5-6<367:AAKIOM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR OLIVARY NEURONS; PHENCYCLIDINE; MEMANTINE; PURKINJE; GRANULE; MOUSE;
Keywords:
LURCHER MUTANT; CEREBELLUM; KETAMINE; NMDA ANTAGONIST;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Lalonde et al., "AMANTADINE AND KETAMINE-INDUCED IMPROVEMENT OF MOTOR COORDINATION IN LURCHER MUTANT MICE", Restorative neurology and neuroscience, 5(5-6), 1993, pp. 367-370

Abstract

The effects of amantadine and ketamine were compared to a placebo in a coat-hanger test on lurcher mutant mice. This test measures motor coordination and is dependent on cerebellar functioning. Both drugs improved motor coordination of the cerebellar mutants in that the time taken to reach the side-bar according to a 2 paw criterion was decreased during the drugged condition in comparison to the non-drugged condition. This result indicates that NMDA receptor antagonists may improve motor coordination in animals with cerebellar disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:31:03