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Titolo:
THERAPEUTIC POTENTIAL OF EXCITATORY AMINO-ACID ANTAGONISTS - CHANNEL BLOCKERS AND 2,3-BENZODIAZEPINES
Autore:
ROGAWSKI MA;
Indirizzi:
NINCDS,DIV INTRAMURAL RES,EPILEPSY RES BRANCH,NEURONAL EXCITABIL SECTBETHESDA MD 20892
Titolo Testata:
Trends in pharmacological sciences
fascicolo: 9, volume: 14, anno: 1993,
pagine: 325 - 331
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE ANTAGONIST; NON-NMDA ANTAGONISTS; ANTICONVULSANT ACTIVITY; RECEPTOR ANTAGONIST; PARKINSONS-DISEASE; PHENCYCLIDINE-LIKE; GYKI 52466; RAT-BRAIN; MEMANTINE; GYKI-52466;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Rogawski, "THERAPEUTIC POTENTIAL OF EXCITATORY AMINO-ACID ANTAGONISTS - CHANNEL BLOCKERS AND 2,3-BENZODIAZEPINES", Trends in pharmacological sciences, 14(9), 1993, pp. 325-331

Abstract

NMDA and non-NMDA (AMPA/kainate) antagonists have potential in the treatment of a diverse group of neurological disorders associated with excessive activation of excitatory amino acid receptors. Here Michael Rogawski reviews recent progress in the development of therapeutically useful NMDA receptor channel blockers and a new class of selective AMPA/kainate receptor antagonists, the 2,3-benzodiazepines. Research on these novel noncompetitive excitatory amino acid antagonists has openedpromising new avenues for the development of drugs to treat epilepsy,ischaemia, neurogeneration and Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:06:23