Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY AND 1-YEAR OUTCOME IN DEPRESSION
Autore:
ROTHSCHILD AJ; SAMSON JA; BOND TC; LUCIANA MM; SCHILDKRAUT JJ; SCHATZBERG AF;
Indirizzi:
MCLEAN HOSP,AFFECT DIS PROGRAM,DEPRESS RES FACIL,115 MILL ST BELMONT MA 02178 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02115 STANFORD UNIV,MED CTR,SCH MED,DEPT PSYCHIAT STANFORD CA 94305
Titolo Testata:
Biological psychiatry
fascicolo: 6, volume: 34, anno: 1993,
pagine: 392 - 400
SICI:
0006-3223(1993)34:6<392:HAAA1O>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; MAJOR DEPRESSION; FOLLOW-UP; CORTISOL HYPERSECRETION; DELUSIONAL DEPRESSION; PSYCHOTIC DEPRESSION; SOCIAL ADJUSTMENT; CUSHINGS-SYNDROME; SELF-REPORT; DISORDER;
Keywords:
HPA AXIS; OUTCOME IN DEPRESSION; URINARY FREE CORTISOL; PSYCHOTIC DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; SOCIAL AND OCCUPATIONAL FUNCTIONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Rothschild et al., "HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY AND 1-YEAR OUTCOME IN DEPRESSION", Biological psychiatry, 34(6), 1993, pp. 392-400

Abstract

The relationships of longitudinal biological measures to longer-term outcome in depressed patients have not been well explored. This study was designed to investigate whether in a sample of depressed patients:(a) symptomatic and functional outcome at 1 year was significantly different in psychotic major depressed (PMD) patients as compared with nonpsychotic major depressed (NPMD) patients and (b) high urinary or plasma cortisol levels at baseline or 1 year were associated with pooreroutcomes at 1 year. Forty-two depressed patients (9 psychotic, 33 nonpsychotic) were evaluated at baseline and at 1 year using a battery ofclinical ratings and measures of cortisol. A group of normal, healthycontrol subjects were similarly evaluated at baseline. At 1-year follow-up, PMD patients did not differ from NPMD patients in their Hamilton Depression Rating Scale (HDRS) and Brief Psychiatric Rating Scale scores (BPRS), but PMD patients demonstrated significantly poorer socialand occupational functioning. Significant correlations were observed (n = 18) between higher levels of urinary and plasma cortisol at 1 year and poorer social and occupational functioning at 1 year, independent of the degree of residual depression. In contrast, baseline measuresof urinary and plasma cortisol did not predict social and occupational functioning at 1 year.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/11/20 alle ore 03:24:40