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Titolo:
THE CORTISOL RESPONSE TO CLONIDINE IN ACUTE AND REMITTED DEPRESSED MEN
Autore:
TRESTMAN RL; COCCARO EF; MITROPOULOU V; GABRIEL SM; HORVATH T; SIEVER LJ;
Indirizzi:
BRONX VET ADM MED CTR,PSYCHIAT SERV,116A,130 W KINGSBRIDGE RD BRONX NY 10468 CUNY MT SINAI SCH MED NEW YORK NY 10029 MED COLL PENN PHILADELPHIA PA 19129
Titolo Testata:
Biological psychiatry
fascicolo: 6, volume: 34, anno: 1993,
pagine: 373 - 379
SICI:
0006-3223(1993)34:6<373:TCRTCI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; GROWTH-HORMONE; PLASMA-CORTISOL; BLOOD-PRESSURE; ENDOGENOUS-DEPRESSION; NORADRENERGIC NEURONS; LOCUS COERULEUS; SECRETION; ACTH; NORADRENALINE;
Keywords:
DEPRESSION; CLONIDINE; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Trestman et al., "THE CORTISOL RESPONSE TO CLONIDINE IN ACUTE AND REMITTED DEPRESSED MEN", Biological psychiatry, 34(6), 1993, pp. 373-379

Abstract

To assess the relationship between the hypothalamo-pituitary-adrenal (HPA) axis and the noradrenergic system in patients with major depression, 26 normal controls, 32 acutely depressed patients, and 21 patients with remitted depression, all men, were administered intravenous clonidine (2 mug/kg) or placebo. Acute, but not remitted, depressed patients had a greater plasma cortisol baseline than did normal controls (t= 2.0, p < 0.03). Only acutely depressed patients had a greater decrease in plasma cortisol in response to clonidine than to placebo (t = 2.5, p < 0.02). Statistically controlling for both diurnal variation and baseline cortisol, acute, but not remitted, depressed patients had agreater decrease in plasma cortisol in response to clonidine than didthe controls (analysis of covariance: F[1,35] = 4.26, p < 0.05). These results support a state-dependent noradrenergic-HPA axis regulatory disturbance in depressed patients, suggesting that clonidine inhibits the elevated plasma cortisol in acute depression but not the normal concentrations observed in remitted depression or healthy controls.

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Documento generato il 21/01/20 alle ore 01:26:03