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Titolo:
EFFECT OF HELICOBACTER-PYLORI ERADICATION ON ANTRAL GASTRIN-IMMUNOREACTIVE AND SOMATOSTATIN-IMMUNOREACTIVE CELL-DENSITY AND GASTRIN AND SOMATOSTATIN CONCENTRATIONS
Autore:
QUEIROZ DMM; MENDES EN; ROCHA GA; MOURA SB; RESENDE LMH; BARBOSA AJA; COELHO LGV; PASSOS MCE; CASTRO LP; OLIVEIRA CA; LIMA GF;
Indirizzi:
FED UNIV MINAS GERAIS,FAC MED,RES BACTERIOL LAB,AV ALFREDO BALENA 190-464 BR-30130 BELO HORIZON MG BRAZIL FED UNIV MINAS GERAIS,FAC MED,DEPT PATHOL BR-30130 BELO HORIZON MG BRAZIL FED UNIV MINAS GERAIS,FAC MED,DEPT MED BR-30130 BELO HORIZON MG BRAZIL
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 10, volume: 28, anno: 1993,
pagine: 858 - 864
SICI:
0036-5521(1993)28:10<858:EOHEOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL-ULCER PATIENTS; PERFUSED RAT STOMACH; CAMPYLOBACTER-PYLORI; ACID-SECRETION; PLASMA GASTRIN; GENE-EXPRESSION; UREASE ACTIVITY; INHIBITION; RELEASE; HYPERGASTRINEMIA;
Keywords:
ANTRAL D-CELLS; ANTRAL GASTRIN; ANTRAL G-CELLS; ANTRAL SOMATOSTATIN; HELICOBACTER-PYLORI INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.M.M. Queiroz et al., "EFFECT OF HELICOBACTER-PYLORI ERADICATION ON ANTRAL GASTRIN-IMMUNOREACTIVE AND SOMATOSTATIN-IMMUNOREACTIVE CELL-DENSITY AND GASTRIN AND SOMATOSTATIN CONCENTRATIONS", Scandinavian journal of gastroenterology, 28(10), 1993, pp. 858-864

Abstract

The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. Thenumber of oxyntic D-cells did not change significantly. These resultsstrongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:22:57