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Titolo:
NEUROLEPTICS INCREASE STRIATAL ACETYLCHOLINE-RELEASE BY A SEQUENTIAL D-1 AND D-2 RECEPTOR MECHANISM
Autore:
RUSSI G; GIROTTI P; CADONI C; DICHIARA G; CONSOLO S;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62 I-20157 MILAN ITALY MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62 I-20157 MILAN ITALY UNIV CAGLIARI,DEPT TOXICOL I-09100 CAGLIARI ITALY
Titolo Testata:
NeuroReport
fascicolo: 12, volume: 4, anno: 1993,
pagine: 1335 - 1338
SICI:
0959-4965(1993)4:12<1335:NISABA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATUM; DOPAMINERGIC REGULATION; ENDOGENOUS DOPAMINE; INVIVO; D1-RECEPTOR; METABOLISM; AGONISTS; DIALYSIS; DRUGS; D1;
Keywords:
(-) REMOXIPRIDE; MICRODIALYSIS TECHNIQUE; SCH-23390; DA AUTORECEPTORS; ALPHA-METHYL-P-TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
G. Russi et al., "NEUROLEPTICS INCREASE STRIATAL ACETYLCHOLINE-RELEASE BY A SEQUENTIAL D-1 AND D-2 RECEPTOR MECHANISM", NeuroReport, 4(12), 1993, pp. 1335-1338

Abstract

IN normal striata, pre-treatment with the D-1 antagonist SCH 23390 (250 and 25 mug kg-1, s.c.) completely and lastingly prevented the D-2 antagonist renioxipride (REM) from increasing acetylcholine (ACh) release; post-treatment did not affect REM action. In alpha-methyl-p-tyrosine (alpha-MpT) dopamine (DA)-depleted striata, however, pre-treatment with SCH 23390 resulted in a transient impairment of REM induced stimulation of ACh release but post-treatment still had no effect. Two different mechanisms therefore seem to be involved in D-2 antagonist-induced stimulation of ACh release; the antagonists indirectly activate a D-1 receptor-mediated facilitatory mechanism regulating cholinergic function, and directly block a D-2 receptor-mediated inhibitory one. In normal rats, in an early phase after D-2 antagonist administration, only the first mechanism is operative; in a later phase, both mechanisms cooperate in the stimulation of ACh release. When DA release is impaired by alpha-MpT, the D-2 inhibitory receptor mechanism becomes more important than the D-1 facilitatory one in controlling ACh release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:49:42