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Titolo:
THE OGD1-MUTANT AND KGD1-MUTANT LACKING 2-OXOGLUTARATE DEHYDROGENASE-ACTIVITY IN YEAST ARE ALLELIC AND CAN BE DIFFERENTIATED BY THE CLONED AMBER SUPPRESSOR
Autore:
MOCKOVCIAKOVA D; JANITOROVA V; ZIGOVA M; KACLIKOVA E; ZAGULSKI M; SUBIK J;
Indirizzi:
COMENIUS UNIV BRATISLAVA,DEPT MICROBIOL & VIROL,MLYNSKA DOLINA B-2 CS-84215 BRATISLAVA CZECHOSLOVAKIA COMENIUS UNIV BRATISLAVA,DEPT MICROBIOL & VIROL,MLYNSKA DOLINA B-2 CS-84215 BRATISLAVA CZECHOSLOVAKIA FOOD RES INST CS-82006 BRATISLAVA CZECHOSLOVAKIA POLISH ACAD SCI,INST BIOCHEM & BIOPHYS PL-02532 WARSAW POLAND
Titolo Testata:
Current genetics
fascicolo: 5, volume: 24, anno: 1993,
pagine: 377 - 381
SICI:
0172-8083(1993)24:5<377:TOAKL2>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-KETOGLUTARATE DEHYDROGENASE; SACCHAROMYCES-CEREVISIAE; LIPOAMIDE DEHYDROGENASE; STRUCTURAL GENE; TRANSFORMATION; CLONING; DNA;
Keywords:
2-OXOGLUTARATE DEHYDROGENASE; MOLECULAR CLONING; SACCHAROMYCES-CEREVISIAE; SEQUENCING; SUPPRESSOR; YEAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D. Mockovciakova et al., "THE OGD1-MUTANT AND KGD1-MUTANT LACKING 2-OXOGLUTARATE DEHYDROGENASE-ACTIVITY IN YEAST ARE ALLELIC AND CAN BE DIFFERENTIATED BY THE CLONED AMBER SUPPRESSOR", Current genetics, 24(5), 1993, pp. 377-381

Abstract

The activity of mitochondrial 2-oxoglutarate dehydrogenase in S. cerevisiae can be impaired either by the ogd1 or the kgd1 mutation. The OGD1 gene and two suppressor genes were isolated by complementation of the ogd1 mutant. The complementation of the kdg1 mutant by the OGD1 gene, an allelism test, and meiotic mapping, revealed that the ogd1 and kgd1 mutations are allelic. The two mutations were differentiated by the cloned suppressor gene which was able to partially complement ogd1, but not kgd1. The molecular analysis of the suppressor gene revealed its identity with the natural tRNA(CAG)Gln gene found in the upstream region of URA10.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:44:37