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Titolo:
SERIAL CHANGES OF PLASMA PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY IN ACUTE MYOCARDIAL-INFARCTION - DIFFERENCE BETWEEN THROMBOLYTIC THERAPY AND DIRECT CORONARY ANGIOPLASTY
Autore:
HIRASHIMA O; OGAWA H; OSHIMA S; SAKAMOTO T; HONDA Y; SAKATA S; MASUDA T; MIYAO Y; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,1-1-1 HONJO KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DIV CARDIOL KUMAMOTO 860 JAPAN FUKUOKA TOKUSHUKAI HOSP,DIV CARDIOL FUKUOKA JAPAN
Titolo Testata:
The American heart journal
fascicolo: 5, volume: 130, anno: 1995,
pagine: 933 - 939
SICI:
0002-8703(1995)130:5<933:SCOPPI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS STREPTOKINASE; IMMEDIATE ANGIOPLASTY; T-PA; TRIAL; ARTERY; REOCCLUSION; REPERFUSION; PATENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
O. Hirashima et al., "SERIAL CHANGES OF PLASMA PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY IN ACUTE MYOCARDIAL-INFARCTION - DIFFERENCE BETWEEN THROMBOLYTIC THERAPY AND DIRECT CORONARY ANGIOPLASTY", The American heart journal, 130(5), 1995, pp. 933-939

Abstract

The fibrinolytic system is impaired in patients with acute myocardialinfarction (AMI). The primary regulatory element of fibrinolytic activity is plasminogen activator inhibitor (PAI). There are no reports, however, on the serial changes of PAI activity after thrombolysis or coronary angioplasty in patients with AMI undergoing emergency coronary angiography. This study was designed to examine the difference in the change of fibrinolytic activity between patients with AMI who underwent thrombolytic therapy with recombinant tissue-plasminogen activator (rTPA) and those who underwent direct percutaneous coronary angioplasty(PTCA). We measured the serial changes of PAI activity end tissue plasminogen activator (TPA) antigen after rTPA therapy or direct PTCA. Twenty-two patients received emergency coronary angiography and were treated with rTPA intravenously. Twenty patients underwent direct PTCA. Plasma PAI activity levels were increased on admission and further increased within 24 hours in patients treated with rTPA and in those treated with direct PTCA. In the thrombolysis group, there were two peaks in plasma PAI activity levels (IU/ml) at 4 hours (27.0 +/- 2.9) and at 16 hours (25.6 +/- 2.5) after the initiation of rTPA infusion. However, in the direct PTCA group, there was one peak of PAI activity (IU/ml)at 16 hours (23.9 +/- 2.7) after the initiation of direct PTCA. In conclusion, the PAI activity has two peaks in the thrombolysis group andone peak in the direct PTCA group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:55:48