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Titolo:
GENERALIZED AUTOIMMUNE-DISEASE IN INTERLEUKIN-2-DEFICIENT MICE IS TRIGGERED BY AN UNCONTROLLED ACTIVATION AND PROLIFERATION OF CD4(-CELLS()T)
Autore:
SADLACK B; LOHLER J; SCHORLE H; KLEBB G; HABER H; SICKEL E; NOELLE RJ; HORAK I;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY UNIV WURZBURG,INST VIROL & IMMUNOBIOL D-97078 WURZBURG GERMANY UNIV HAMBURG,HEINRICH PETTE INST HAMBURG GERMANY CENT INST LAB ANIM BREEDING HANNOVER GERMANY DARTMOUTH COLL SCH MED,DEPT MICROBIOL LEBANON NH 00000
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 25, anno: 1995,
pagine: 3053 - 3059
SICI:
0014-2980(1995)25:11<3053:GAIIMI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; DEFICIENT; ANTIBODY;
Keywords:
INTERLEUKIN-2; AUTOIMMUNITY; KNOCKOUT MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
B. Sadlack et al., "GENERALIZED AUTOIMMUNE-DISEASE IN INTERLEUKIN-2-DEFICIENT MICE IS TRIGGERED BY AN UNCONTROLLED ACTIVATION AND PROLIFERATION OF CD4(-CELLS()T)", European Journal of Immunology, 25(11), 1995, pp. 3053-3059

Abstract

Interleukin-2-deficient mice (IL-2(-/-)) crossed to a BALB/c genetic background develop a lymphoproliferative syndrome with severe hemolytic anemia and die within 5 weeks of age. The presence of autoantibodiesof various specificities and inflammatory lesions in several organs are indicative of a generalized autoimmune disease. No alterations of the immune system were observed in 6-day-old animals, but 10-day-old mice already showed an increased proliferation and polyclonal activationof lymphocytes. The treatment of IL-2(-/-) mice with anti-gp39(CD40L)antibody prevented the disease and indicated that the appearance of activated CD4(+) T cells (CD44(high), CD69(+)) represents the first alteration of the immune system in IL-2(-/-) mice. Collectively, our results suggest that an essential role of IL-2 in vivo, which is not compensated by other cytokines, is the maintenance of self tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:32:02