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Titolo:
MICROVASCULAR DISEASE AND ANASTOMOTIC DEHISCENCE IN THE COLON
Autore:
FAWCETT A; VASHISHT R; SHANKAR A; DAWSON PM; OMALLEY MK; NOTT DM; SPRINGALL RG;
Indirizzi:
CHARING CROSS HOSP,DEPT SURG,FULHAM PALACE RD LONDON W6 8RF ENGLAND CHARING CROSS HOSP,DEPT SURG LONDON W6 8RF ENGLAND W MIDDLESEX UNIV HOSP ISLEWORTH ENGLAND MATER MISERICORDIAE HOSP DUBLIN 7 IRELAND
Titolo Testata:
British Journal of Surgery
fascicolo: 11, volume: 82, anno: 1995,
pagine: 1483 - 1485
SICI:
0007-1323(1995)82:11<1483:MDAADI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC MONKEYS; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Fawcett et al., "MICROVASCULAR DISEASE AND ANASTOMOTIC DEHISCENCE IN THE COLON", British Journal of Surgery, 82(11), 1995, pp. 1483-1485

Abstract

Platelet-derived serotonin released in response to tissue manipulation during surgery may contribute to mesenteric arterial vasospasm leading to postoperative anastomotic leakage, after colorectal resection. Organ bath experiments were used to demonstrate the efficacy of naftidrofuryl fumarate (NFT) to oppose serotonin-induced vasoconstriction of human mesenteric arteries. Cumulative dose-response curves were derived with and without NFT at 10(-9) and 10(-6) mol/l concentrations. The difference in maximal contractility between the three sets of curves (n = 8 for each) was significant (P < 0.0001). Sensitivity to serotoninin each of the three curves was measured by calculating the concentration for half-maximal response; differences were again significant (P < 0.0001). NFT reduced serotonin-induced contractility in a dose-dependent fashion in rings of human mesenteric arteries in vitro. This suggests a possible role for NFT in reducing mesenteric vasospasm in colorectal surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:26:05