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Titolo:
DRUG-INDUCED HEAT-SHOCK PRECONDITIONING IMPROVES POSTISCHEMIC VENTRICULAR RECOVERY AFTER CARDIOPULMONARY BYPASS
Autore:
MAULIK N; ENGELMAN RM; WEI ZJ; LIU XK; ROUSOU JA; FLACK JE; DEATON DW; DAS DK;
Indirizzi:
UNIV CONNECTICUT,SCH MED,DEPT SURG,SURG RES CTR,DIV CARDIOVASC FARMINGTON CT 06030 UNIV CONNECTICUT,SCH MED,DEPT SURG,SURG RES CTR,DIV CARDIOVASC FARMINGTON CT 06030 BAYSTATE MED CTR,DEPT SURG SPRINGFIELD MA 01107
Titolo Testata:
Circulation
fascicolo: 9, volume: 92, anno: 1995, supplemento:, S
pagine: 381 - 388
SICI:
0009-7322(1995)92:9<381:DHPIPV>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR ADAPTATION; MYOCARDIAL SALVAGE; INFARCT SIZE; RABBIT HEART; RAT HEARTS; ISCHEMIA; PROTEINS; STRESS; HYPERTHERMIA; REPERFUSION;
Keywords:
PROTEINS; GENES; AMPHETAMINE; ISCHEMIA; ANTIOXIDANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
N. Maulik et al., "DRUG-INDUCED HEAT-SHOCK PRECONDITIONING IMPROVES POSTISCHEMIC VENTRICULAR RECOVERY AFTER CARDIOPULMONARY BYPASS", Circulation, 92(9), 1995, pp. 381-388

Abstract

Background Heat-stress preconditioning of mammalian heart has been found to confer protection against ischemic reperfusion injury. Heat shock is generally provided by warming the animal by mechanical means, which is often impractical in a clinical setting. Amphetamine, a sympathomimetic drug, can elevate the body temperature as a result of enhanced endogenous lipolysis. In this study, we examined the effects of heatshock induced by amphetamine on postischemic myocardial recovery in asetting of coronary revascularization for acute myocardial infarction. Methods and Results Adult Yorkshire swine were injected with amphetamine (3 mg/kg IM) (n=12), and body temperature was continuously monitored. For control studies, the pigs were injected with saline (n=12). Five swine in each group were killed after 3 hours to obtain biopsies of vital organs to measure heat-shock protein (HSP) mRNAs. After 40 hours, the remaining 7 pigs in each group were placed on cardiopulmonary bypass, and the isolated, in situ heart preparations were subjected to1 hour of occlusion of the left anterior descending coronary artery followed by 1 hour of global hypothermic cardioplegic arrest and 1 hourof reperfusion. Postischemic myocardial performance was monitored by measuring left ventricular (LV) pressure, its dP/dt, myocardial segment shortening, and coronary blood flow. Cellular injury was examined bymeasurement of creatine kinase release. The antioxidant enzymes superoxide dismutase and catalase were also assayed. Amphetamine treatment was associated with the induction of mRNAs for HSP 27, HSP 70, and HSP89 in all the vital organs, including heart, lung, liver, kidney, andbrain. Amphetamine also enhanced superoxide dismutase and catalase activities in the heart. Significantly greater recovery of LV contractile functions was noticed, as demonstrated by improved recovery of LV developed pressure (61% versus 52%), LV dP/dt(max) (52% versus 44%), andsegment shortening (46.2% versus 10%) and reduced creatine kinase release in the amphetamine group. Conclusions The results demonstrate that amphetamine can induce whole-body heat shock that can precondition the heart, enhancing cellular tolerance to ischemia-reperfusion injury. Amphetamine is a sympathomimetic drug that may be used for preconditioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:53:10