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Titolo:
CHARACTERIZATION OF HIBERNATING AND STUNNED MYOCARDIUM
Autore:
SCHULZ R; HEUSCH G;
Indirizzi:
UNIV ESSEN GESAMTHSCH KLINIKUM,ZENTRUM INNERE MED,PATHOPHYSIOL ABT,HUFELANDSTR 55 D-45122 ESSEN GERMANY UNIV ESSEN GESAMTHSCH KLINIKUM,ZENTRUM INNERE MED,PATHOPHYSIOL ABT D-45122 ESSEN GERMANY
Titolo Testata:
European heart journal
, volume: 16, anno: 1995, supplemento:, J
pagine: 19 - 25
SICI:
0195-668X(1995)16:<19:COHASM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; FREE-RADICAL GENERATION; REGIONAL BLOOD-FLOW; REPERFUSED CANINE MYOCARDIUM; CORONARY-ARTERY REPERFUSION; TRANS-LUMINAL ANGIOPLASTY; CONTRACTILE FUNCTION; CONSCIOUS DOGS; INOTROPIC RESERVE; TIME-COURSE;
Keywords:
MYOCARDIAL ISCHEMIA; REPERFUSION; HIBERNATION; STUNNING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
107
Recensione:
Indirizzi per estratti:
Citazione:
R. Schulz e G. Heusch, "CHARACTERIZATION OF HIBERNATING AND STUNNED MYOCARDIUM", European heart journal, 16, 1995, pp. 19-25

Abstract

Both the hibernating and the stunned myocardium are characterized by reversible contractile dysfunction. In hibernating myocardium, perfusion is still reduced, whereas in stunned myocardium blood flow is fullyor almost fully restored. Both the hibernating and the stunned myocardium retain an inotropic reserve. In hibernating myocardium the increase in contractile function is at the expense of metabolic recovery, whereas in the stunned myocardium no metabolic deterioration occurs during inotropic stimulation. Therefore, inotropic stimulation in combination with metabolic imaging may help not only to identify viable, dysfunctional myocardium but also to distinguish hibernating and stunned myocardium. The therapy of hibernating myocardium is to restore blood flow to the hypoperfused tissue. Myocardial stunning per se requires no therapy at all, since, by definition, blood flow is normal and contractile function will recover spontaneously. If, however, myocardial stunning is severe, and it involves large parts of the LV and thus impairsglobal LV function, it can be reversed with inotropic agents and procedures. In the experimental setting, anti-oxidant agents, calcium antagonists and ACE inhibitors attenuate stunning, but most effectively when administered before ischaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:21:01